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Intermediates&Fine Chemicals

4-(Trifluoromethoxy)benzoic acid

Category:

Intermediates&Fine Chemicals

CAS NO:

330-12-1

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa

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Hangzhou Verychem Science And Technology Co.Ltd.

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Basic Info

CAS Number

330-12-1

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Samples Provided

Product Description

pharmaceutical intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

4-(Trifluoromethoxy)benzoic acid is a specialized organic intermediate widely utilized in the pharmaceutical and agrochemical industries for the synthesis of complex bioactive molecules. With the chemical formula C8H5F3O3 and the CAS Registry Number 106-92-7, this compound features a benzoic acid core substituted with a trifluoromethoxy group at the para position. The presence of the highly electronegative trifluoromethoxy moiety significantly alters the electronic and lipophilic properties of the parent molecule, often enhancing metabolic stability and membrane permeability in drug candidates. In medicinal chemistry, this reagent serves as a crucial building block for developing non-steroidal anti-inflammatory drugs (NSAIDs), antihypertensive agents, and various kinase inhibitors. Researchers frequently employ it to construct libraries of fluorinated compounds, which are known to exhibit improved pharmacokinetic profiles compared to their non-fluorinated analogs. The electron-withdrawing nature of the -OCF3 group facilitates specific electrophilic aromatic substitution reactions and allows for precise modulation of acidity in subsequent synthetic steps. Beyond pharmaceutical applications, 4-(trifluoromethoxy)benzoic acid finds utility in the development of advanced agrochemicals, including herbicides and fungicides designed to target specific pest pathways while minimizing environmental persistence. Its structural versatility makes it an ideal precursor for coupling reactions, such as amide bond formation or esterification, enabling the creation of diverse molecular architectures. Furthermore, the compound is occasionally used in materials science for synthesizing functional polymers that require specific dielectric or thermal properties due to the unique characteristics of the trifluoromethoxy substituent. Handling this substance requires standard laboratory safety precautions, as it may be irritating to skin and eyes. It is typically stored in a cool, dry place away from incompatible oxidizing agents. As demand for fluorinated organic intermediates grows within the global chemical market, 4-(trifluoromethoxy)benzoic acid remains a pivotal component in the efficient production of next-generation therapeutic agents and high-performance materials. Its availability from major chemical suppliers ensures consistent supply chains for research institutions and commercial manufacturing facilities aiming to innovate in the field of heterocyclic chemistry and drug discovery.