4-Chloro-3-nitropyridine is a very important pyridine derivative, it can be used as a viscosity modifier, can synthesize anti-peptic ulcer drug perilenzepine, diazepine anti-AIDS Chemicalbook disease, leukotriene biosynthesis inhibitor, and can be used as a drug intermediate of insecticides, therefore, the study of 4-chloro-3-nitropyridine synthesis is of great significance