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Other Specialized Reagents

3-Trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

Category:

Other Specialized Reagents

CAS NO:

CAS NO.762240-92-6

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia

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Basic Info

CAS Number

CAS NO.762240-92-6

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Huateng Pharma, a global supplier of pharmaceutical intermediates, PEG derivatives and other chemical products, offers CAS NO.762240-92-6 for your requirements of R&D, evaluation, pilots and commercial along with supportive technical package required for evaluation.

Application: Sitagliptin intermediate.

AI Product Description

*The following content is generated by AI and is for reference only.

3-Trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride is a specialized heterocyclic organic compound widely utilized in medicinal chemistry and pharmaceutical research. Its molecular formula is C₇H₁₀F₃N₅·HCl, reflecting the presence of a trifluoromethyl group attached to a fused triazolopyrazine core, stabilized as a hydrochloride salt to enhance solubility and stability for laboratory handling. The CAS number for this specific chemical entity is 101096-84-4. This compound serves primarily as a valuable intermediate or scaffold in the synthesis of novel bioactive molecules, particularly those targeting central nervous system disorders and metabolic diseases. The incorporation of the trifluoromethyl moiety is strategically significant in drug design, as it often improves metabolic stability, lipophilicity, and binding affinity to target proteins compared to non-fluorinated analogs. Consequently, derivatives of this structure are frequently explored for their potential pharmacological activities, including modulation of neurotransmitter receptors or inhibition of specific enzymes involved in disease pathways. Researchers employ this reagent in high-throughput screening campaigns to identify lead compounds with optimized therapeutic profiles. Due to its salt form, the hydrochloride variant ensures better aqueous solubility, facilitating its use in biological assays and in vitro experiments where precise dosing is critical. While not currently a commercial active pharmaceutical ingredient itself, this molecule represents a crucial building block in the pipeline of modern drug discovery. Its unique structural features allow chemists to fine-tune physicochemical properties during the optimization phase of new drug development. Laboratories specializing in organic synthesis and medicinal chemistry procure this substance to construct complex libraries of heterocycles. Strict adherence to safety protocols is recommended when handling this material, as with most synthetic intermediates, due to potential irritant properties. Overall, 3-Trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride remains an essential tool for advancing the frontiers of heterocyclic chemistry and developing next-generation therapeutics with improved efficacy and safety margins.