3-Cyano-4-isopropoxybenzoic acid is a useful reagent for the preparation of cyanoepoxydiazole substituted azheterocycles as an agonist of sparing sphingophosphate receptors S1P1 and S1P5 for the treatment of multiple sclerosis and its pharmacokinetics and side effects. Diaryl oxadiazole as a preparative agent for S1P1 receptor agonists and SAR.