Product Description
熔点:-8°C沸点:149-151°C(lit.)密度:1.567g/mLat25°C(lit.)折射率:n20/D1.526(lit.)闪点:102°F储存条件:Sealedindry,RoomTemperature溶解度:Chemicalbook0.4g/l形态:Liquid比重:1.567颜色:Clearcolorlesstolightyellow水溶解性:insolubleBRN:1853969InChIKey:QDFKKJYEIFBEFC-UHFFFAOYSA-N
AI Product Description
*The following content is generated by AI and is for reference only.
3-Bromofluorobenzene is a versatile aromatic halide widely utilized in organic synthesis and pharmaceutical research. Its chemical formula is C6H4BrF, and it carries the CAS Registry Number 457-02-9. This compound features a benzene ring substituted with a bromine atom at the meta position relative to a fluorine atom. The presence of both halogen substituents imparts unique reactivity patterns, making it an invaluable building block for constructing complex molecular architectures.
The primary application of 3-bromofluorobenzene lies in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Heck, and Sonogashira couplings. In these transformations, the carbon-bromine bond serves as a reactive site, allowing chemists to attach various functional groups like aryl boronic acids, alkynes, or amines. Meanwhile, the fluorine atom remains largely inert under standard coupling conditions but can be strategically manipulated later to tune the electronic properties or metabolic stability of the final drug candidate. Consequently, this molecule is frequently employed in the development of novel agrochemicals, liquid crystals, and advanced materials.
In the pharmaceutical industry, 3-bromofluorobenzene derivatives are often found in the core structures of bioactive compounds. The specific substitution pattern helps researchers explore structure-activity relationships (SAR) by introducing steric bulk or altering electron density distribution within a target protein binding pocket. Furthermore, its relatively low cost and commercial availability make it a preferred starting material for academic laboratories and industrial R&D departments conducting high-throughput screening campaigns.
Safety protocols must be observed when handling this substance, as it is considered toxic if swallowed, inhaled, or absorbed through the skin. Proper personal protective equipment, including gloves and goggles, along with working in a well-ventilated fume hood, is essential to prevent exposure. Storage should be conducted in a cool, dry place away from incompatible oxidizing agents to ensure stability. Overall, 3-bromofluorobenzene stands as a critical intermediate in modern synthetic chemistry, bridging the gap between simple precursors and sophisticated functional molecules required for cutting-edge scientific advancements.
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