2-Methoxy-5-fluoropyridine can be used in the preparation of 2-methoxy-3-bromo-5-fluoropyridine, which is an important pharmaceutical intermediate and an important fragment of the second-generation TRK inhibitor Chemicalbook LOXO-195. At present, the research and development of new drugs for this target at home and abroad is in a stage of rapid development, and there is a large demand for this intermediate in the future.