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Intermediates&Fine Chemicals

2-(3-(trifluoromethyl)phenyl)malonic acid

Category:

Intermediates&Fine Chemicals

CAS NO:

144758-28-1

Standard:

In-house Standards,

Price Range:

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North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa

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Hangzhou Verychem Science And Technology Co.Ltd.

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Basic Info

CAS Number

144758-28-1

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Samples Provided

Product Description

pharmaceutical intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

2-(3-(Trifluoromethyl)phenyl)malonic acid is a specialized organic intermediate widely utilized in the pharmaceutical and agrochemical industries for the synthesis of complex heterocyclic compounds. With the Chemical Abstracts Service (CAS) Registry Number 101674-85-9, this compound features a malonic acid backbone substituted at the alpha position with a meta-trifluoromethylphenyl group. Its molecular formula is C₁₀H₇F₃O₄, corresponding to a molar mass of approximately 244.16 g/mol. The presence of the electron-withdrawing trifluoromethyl (-CF₃) group significantly enhances the lipophilicity and metabolic stability of molecules derived from it, making it a valuable building block for drug discovery programs aiming to improve pharmacokinetic profiles. The primary application of this reagent lies in its ability to undergo decarboxylation reactions to yield substituted acetophenones or to participate in condensation reactions forming pyridines, quinolines, and other nitrogen-containing heterocycles. These heterocyclic scaffolds are fundamental structural motifs found in numerous bioactive agents, including anti-inflammatory drugs, kinase inhibitors, and antifungal agents. Furthermore, researchers utilize this compound as a key precursor in the development of novel materials with specific electronic properties due to the unique characteristics of the fluorinated aromatic ring. In laboratory settings, it serves as a critical starting material for medicinal chemists designing libraries of compounds to screen against various biological targets. Handling this substance requires standard safety precautions typical for organic acids, including the use of personal protective equipment to avoid skin and eye contact. While not typically classified as highly hazardous under general transport regulations, proper storage in a cool, dry, and well-ventilated area is essential to maintain purity and prevent decomposition. As demand grows for fluorine-containing pharmaceuticals, the role of 2-(3-(trifluoromethyl)phenyl)malonic acid remains pivotal in advancing synthetic methodologies that lead to more effective therapeutic interventions. Its versatility continues to make it an indispensable component in modern chemical research and industrial manufacturing processes focused on high-value added products.