Product Description
1H-吡唑并[3,4-B]吡啶化学性质熔点:99-101°C沸点:120°C/0.1mmHg(lit.)密度:1.38±0.1g/cm3(Predicted)储存条件:Sealedindry,RoomTemperature溶解度Chemicalbook:Chloroform,EthylAcetate酸度系数(pKa):5.92±0.20(Predicted)形态:Solid颜色:reddish-brownInChIKey:GVLRTOYGRNLSDW-UHFFFAOYSA-N
AI Product Description
*The following content is generated by AI and is for reference only.
1H-Pyrazolo[3,4-b]pyridine is a heterocyclic organic compound belonging to the fused pyrazole-pyridine family. Its molecular formula is C6H5N3, and it carries the CAS Registry Number 20978-82-7. This molecule features a bicyclic structure where a pyrazole ring is fused with a pyridine ring at the 3,4-positions, creating a planar, aromatic system with distinct electronic properties. The nitrogen atoms within the ring system provide multiple sites for hydrogen bonding and coordination, making this scaffold highly valuable in medicinal chemistry and materials science research.
In pharmaceutical applications, 1H-pyrazolo[3,4-b]pyridine serves as a critical building block for synthesizing complex bioactive molecules. Derivatives of this core structure have demonstrated potential pharmacological activities, including anti-inflammatory, antiviral, and anticancer properties. Researchers frequently modify the substituents on the pyrazole or pyridine rings to optimize binding affinity against specific biological targets such as kinases or G-protein coupled receptors. The structural rigidity of the fused system often enhances metabolic stability compared to non-fused analogs, which is a desirable trait for drug candidates.
Beyond medicine, this compound finds utility in agrochemical development, where it acts as a precursor for novel herbicides and fungicides. In materials science, its electron-rich nature allows for integration into organic semiconductors and luminescent materials. The synthesis of 1H-pyrazolo[3,4-b]pyridine typically involves cyclization reactions between appropriate hydrazine derivatives and pyridine precursors, often requiring catalysts or specific temperature controls to ensure regioselectivity. Due to its high reactivity and versatility, it remains a staple intermediate in laboratory-scale organic synthesis.
While primarily used as a research tool rather than a commercial end-product, its derivatives are increasingly appearing in patent literature for therapeutic agents. Handling requires standard laboratory safety precautions due to potential irritation risks. As chemical libraries expand, the demand for pure 1H-pyrazolo[3,4-b]pyridine continues to grow, supporting advancements in drug discovery pipelines and functional material engineering. Its unique electronic configuration ensures continued relevance in the design of next-generation nitrogen-containing heterocycles.
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