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CAS NO:
998-07-2
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Basic Info
CAS Number
998-07-2
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
YES
Product Description
Huateng Pharmaceutical, a global supplier of pharmaceutical intermediates & chemical products & biological reagent & PEG derivatives, offers 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine, CAS NO.998-07-2 for your requirements of R&D, evaluation, pilots and commercial along with supportive technical package required for evaluation.
Application: is a phospholipid serving both structural and functional roles in biological membranes. It is one of the excipients of COVID-19 Vaccines.
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AI Product Description
*The following content is generated by AI and is for reference only.
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine, commonly abbreviated as DMPE, is a synthetic phospholipid widely utilized in biochemical research and pharmaceutical development. With the chemical formula C35H68NO8P and CAS number 4904-75-2, this molecule features a glycerol backbone esterified with two myristic acid chains at the sn-1 and sn-2 positions, linked to a phosphoethanolamine head group at the sn-3 position. The symmetric structure of DMPE makes it an ideal component for constructing model biological membranes, where its specific phase transition temperature allows researchers to study lipid bilayer dynamics under controlled conditions.
The primary application of DMPE lies in the formulation of liposomes and lipid nanoparticles (LNPs). Due to its zwitterionic nature and relatively small headgroup compared to other phospholipids like phosphatidylcholine, DMPE promotes membrane fusion and facilitates the encapsulation of therapeutic agents, including nucleic acids, proteins, and hydrophobic drugs. It is frequently employed in gene delivery systems, where it helps stabilize the nanoparticle structure and enhances cellular uptake efficiency. Furthermore, DMPE serves as a critical reagent in studying membrane protein interactions, enzyme kinetics within lipid environments, and the physical properties of biomimetic interfaces.
In diagnostic applications, fluorescently labeled derivatives of DMPE are used to track membrane dynamics, vesicle trafficking, and cell fusion events in live-cell imaging studies. Its compatibility with various biological buffers and stability under physiological pH make it a versatile tool in both in vitro and in vivo experiments. As the demand for targeted drug delivery systems grows, DMPE remains a foundational building block in nanomedicine, enabling the precise engineering of carrier systems that can traverse biological barriers. Researchers continue to explore its potential in vaccine adjuvants and immunotherapy platforms, leveraging its ability to modulate immune responses through membrane interaction. Overall, 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine stands as an essential commodity in modern biotechnology, bridging fundamental membrane biology with advanced clinical therapeutics.
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