CAS号:2573781-75-4英文名:1-Propanesulfonamide,N-[2-chloro-3-[(3,4-dihydro-3,5-dimethyl-4-oxo-6-quinazolinyl)amino]-4-fluorophenyl]-3-fluoro-英文别名:Tinlorafenib;Tinlorafenib(compound10);1-PropanesuChemicalbooklfonamide,N-[2-chloro-3-[(3,4-dihydro-3,5-dimethyl-4-oxo-6-quinazolinyl)amino]-4-fluorophenyl]-3-fluoro-中文名:化合物TINLORAFENIB中文别名:替洛拉芬尼;化合物TINLORAFENIBCBNumber:CB78387812分子式:C19H19ClF2N4O3S分子量
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N-[2-chloro-3-[(3,4-dihydro-3,5-dimethyl-4-oxo-6-quinazolinyl)amino]-4-fluoropropyl]-1-propanesulfonamide is a sophisticated organic compound belonging to the class of quinazoline derivatives. While specific commercial catalog data for this exact long-chain sulfonamide variant may be limited in open databases due to its specialized nature as an intermediate or research chemical, it shares structural motifs with potent kinase inhibitors and antineoplastic agents commonly found in medicinal chemistry literature. The molecule features a core 3,4-dihydro-3,5-dimethyl-4-oxoquinazoline ring system, which is renowned for its ability to interact with ATP-binding pockets in various protein kinases, alongside a fluorinated propyl chain terminated by a propanesulfonamide group. This unique combination of electron-withdrawing halogens and hydrogen-bonding sulfonamide functionalities suggests high potential for biological activity, particularly in oncology research.
The primary application of such compounds lies in pharmaceutical development, specifically as lead structures for discovering novel anticancer therapeutics. Researchers utilize these molecules to investigate structure-activity relationships (SAR) aimed at enhancing selectivity against tumor-specific kinases while minimizing off-target effects. The presence of the fluorine atom often improves metabolic stability and membrane permeability, crucial properties for drug bioavailability. Furthermore, the quinazoline scaffold has historically been associated with tyrosine kinase inhibition, making this derivative a candidate for targeting epidermal growth factor receptor (EGFR) or similar pathways implicated in malignant cell proliferation. Beyond cancer treatment, variations of this chemical architecture are occasionally explored for their anti-inflammatory or antimicrobial properties, although the dominant focus remains on oncological applications.
Due to its complexity and specific functional groups, this substance is primarily handled within controlled laboratory environments rather than as a consumer product. It serves as a critical building block for synthesizing more complex pharmacophores or as a reference standard in analytical studies. Safety protocols for handling such organosulfur and halogenated compounds are stringent, requiring appropriate personal protective equipment and ventilation to prevent exposure to potentially toxic intermediates. As research continues into targeted therapies, derivatives like N-[2-chloro-3-[(3,4-dihydro-3,5-dimethyl-4-oxo-6-quinazolinyl)amino]-4-fluoropropyl]-1-propanesulfonamide represent significant contributions to the advancement of precision medicine, offering promising avenues for treating resistant cancers that do not respond to conventional chemotherapy regimens.
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