Huateng Pharma is a leading and professional manufacturer which can provide fine chemicals, PEG derivatives, biochemical reagents, pharmaceutical APIs & intermediates, Vitamin D Derivatives for our customers, it offers CAS NO.846038-18-4 for your requirements of R&D, evaluation, pilots and commercial along with supportive technical package required for evaluation.
Application: It is an intermediate of Brexpiprazole.
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1-(Benzo[b]thiophen-4-yl)piperazine is a specialized organic heterocyclic compound widely utilized in medicinal chemistry and pharmaceutical research. With the molecular formula C₁₂H₁₄N₂S, this substance features a unique structural combination of a piperazine ring linked to a benzo[b]thiophene moiety at the fourth position. The specific Chemical Abstracts Service (CAS) registry number for this compound is 205683-89-8. Its chemical architecture, characterized by a sulfur-containing aromatic system fused with a saturated nitrogenous ring, provides a versatile scaffold for synthesizing complex bioactive molecules.
The primary application of 1-(Benzo[b]thiophen-4-yl)piperazine lies in its role as a critical intermediate or building block in drug discovery programs. Researchers frequently employ it to construct libraries of potential therapeutic agents targeting various neurological disorders, including schizophrenia, anxiety, and depression. The piperazine unit is well-known for its ability to interact with serotonin and dopamine receptors, while the benzo[b]thiophene group can modulate lipophilicity and metabolic stability, thereby optimizing pharmacokinetic profiles. Consequently, derivatives synthesized from this precursor often exhibit enhanced binding affinity and selectivity compared to their non-thiophene analogs.
Beyond neuroscience, ongoing studies explore its utility in developing anti-inflammatory and anticancer agents. The sulfur atom within the thiophene ring offers additional opportunities for chemical modification, allowing chemists to introduce diverse functional groups that can fine-tune biological activity. Due to its reactivity and specific structural properties, this compound serves as an essential tool for academic laboratories and industrial R&D departments aiming to accelerate the identification of novel lead compounds. While not typically marketed as a standalone commercial product for general use, high-purity samples are available through specialized chemical suppliers for research purposes only. Strict adherence to safety protocols is recommended when handling this material, as with most synthetic organic intermediates, to ensure laboratory safety and regulatory compliance during synthesis and characterization processes.