储存条件-20°C溶解度可溶于DMSO（轻微加热）、甲醇（轻微）、水（轻微）形态固体颜色白色至黄色Merck13,6697BRN3570187稳定性非常吸湿InChIInChI=1/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/p-4,7-9,Chemicalbook11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/s3InChIKeyDAYLJWODMCOQEW-TURQNECASA-NSMILESO[C@@H]1[C@@H]([C@@H](COP(O)([O-])=O)O[C@H]1[N+]1=CC=CC(C(=O)N)=C1)O|&1:1,2,3,11,r|
*The following content is generated by AI and is for reference only.
β-Nicotinamide Mononucleotide, commonly abbreviated as NMN, is a critical biochemical intermediate in the biosynthesis of Nicotinamide Adenine Dinucleotide (NAD+). With the molecular formula C11H15N2O8P and the CAS Registry Number 1094-61-7, this nucleotide derivative has garnered significant attention in the fields of anti-aging research, metabolic health, and longevity science. Structurally, NMN consists of a nicotinamide riboside moiety linked to a phosphate group, serving as the direct precursor that cells utilize to replenish declining NAD+ levels.
As cellular NAD+ concentrations naturally diminish with age, leading to impaired mitochondrial function, DNA repair deficits, and reduced metabolic efficiency, NMN supplementation has emerged as a promising therapeutic strategy. By bypassing rate-limiting enzymatic steps, oral administration of NMN efficiently elevates intracellular NAD+ pools across various tissues, including the liver, muscle, brain, and heart. Extensive preclinical studies have demonstrated its potential to enhance insulin sensitivity, improve glucose metabolism, boost physical endurance, and protect against neurodegenerative conditions associated with aging. Furthermore, emerging research suggests benefits for cardiovascular health and the mitigation of age-related inflammation.
In the commercial sector, NMN is widely available as a dietary supplement in powder, capsule, and sublingual forms, targeting consumers seeking to optimize vitality and slow the aging process. While regulatory status varies globally, with some jurisdictions classifying it as a novel food or drug ingredient while others permit it as a general supplement, the scientific consensus continues to support its role in metabolic regulation. Although human clinical trials are ongoing to fully validate long-term efficacy and safety profiles, current evidence positions β-Nicotinamide Mononucleotide as a cornerstone molecule in modern geroscience. Its ability to bridge the gap between nutritional biochemistry and age-related disease prevention makes it a focal point for researchers and health enthusiasts alike, offering hope for extending healthspan and maintaining physiological resilience throughout life.
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