Ultimovacs ASA ("Ultimovacs") (OSE ULTI), a clinical stage leader in immune stimulatory vaccines for cancer, today announced the publication of a review of telomerase-based therapeutic cancer vaccines including the Company's universal cancer vaccine, UV1. The article in Frontiers in Immunology examines the broad relevance of telomerase as an attractive cancer target and examines opportunities for optimizing anti-telomerase vaccine performance both by selecting appropriate cancer types and by analyzing the underlying limitations of current standard treatments.
The article focusses on the synergy between telomerase-based cancer vaccines and checkpoint inhibitors. In particular, it highlights areas within cancer treatment where clinical trials have shown that specific combinations of the two components are more effective than either component used alone. Checkpoint inhibitors, of which there are several varieties, have become the standard treatment for many solid tumor types. There is a strong rationale for combining them with telomerase vaccines to boost the activity of cells involved in the anti-cancer immune response.
"This latest article articulates the rationale for using telomerase-targeting cancer vaccines as a key to unlock the full potential of checkpoint inhibitors," stated Carlos de Sousa, Chief Executive Officer at Ultimovacs."For our universal cancer vaccine, UV1, the early read-outs from our combination trial with pembrolizumab indicate that this rationale is playing out well in the clinic."
Ultimovacs recently released data from the first cohort of a Phase I trial where UV1 in combination with pembrolizumab showed a 60% objective response rate (including 30% complete responses) in advanced malignant melanoma, an evident improvement over pembrolizumab alone*. UV1 is currently in clinical development with four randomized, multinational, Phase II combination trials which will recruit over 500 patients in advanced malignant melanoma, ovarian cancer, head-and-neck cancer and malignant pleural mesothelioma.
As the review in Frontiers in Immunology points out, telomerase is an attractive target because it is broadly expressed on 85-90% of all tumor types, especially in metastatic cancer cells. Furthermore, it plays an essential role in cancer cell reproduction, making it difficult for tumor cells to mutate and evade the treatment. Combining telomerase cancer vaccines with checkpoint inhibitors appears to improve overall treatment responses and outcomes by helping to prevent tumors hiding from or disabling patients' immune defenses.
The Frontiers in Immunology review also suggests that, although most of the current clinical trials evaluate treatments of late-stage disease in heavily pre-treated patients, there is potential for telomerase-targeting therapeutic cancer vaccines in earlier disease settings, when the need to combine them with other treatments might be reduced.
About UV1
UV1 is a peptide-based vaccine inducing a specific T cell response against the universal cancer antigen telomerase. UV1 is being developed as an "off-the-shelf" therapeutic cancer vaccine which may serve as a platform for use in combination with other immunotherapy which requires an ongoing T cell response for their mode of action. To date, UV1 has been tested in four phase I clinical trials in a total of 82 patients and maintained a positive safety and tolerability profile as well as encouraging signals of efficacy.
About UV1 Clinical Programs
As a universal cancer vaccine, UV1's unique mechanism of action has the potential to be applicable across most cancer types. The clinical development of the UV1 vaccine includes four randomized, multinational, Phase II combination trials: INITIUM, NIPU, DOVACC and FOCUS, recruiting over 500 patients in total. Ultimovacs anticipates announcing data on the ...
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