What is triamcinolone acetonide?
• Definition
Triamcinolone acetonide cream is a synthetic corticosteroid used to treat different skin conditions. Corticosteroids are believed to decrease inflammation by inhibiting the immune system; this why triamcinolone acetonide cream is used in various inflammatory skin disorders and joint conditions.
Triamcinolone can also be used nasally as a spray to treat allergic rhinitis or as a dental paste to treat mouth ulcers. Call your doctor before considering using triamcinolone. Side effects encountered include burning, itching, irritation or unwanted hair growth.
• Chemical & Physical features (CAS number, molecular formula, powder color, etc.)
Triamcinolone acetonide is a white crystalline powder, and it is insoluble in water and sparingly soluble in dehydrated alcohol, in methanol and in chloroform. Other chemical & physical characteristics of triamcinolone acetonide include:
CAS number: 76-25-5
Chemical name: 9α-Fluoro-11β,16α, 17, 21 tetrahydroxypregna-1,4-diene-3, 20-dione cyclic 16, 17-acetal with acetone (C24H31FO6)
Molar mass: 434.504 g·mol−1
Melting point: 290 to 294 °C (554 to 561 °F)
Clinical pharmacology
The medication is a potent derivate of triamcinolone, and it is a powerful anti-inflammatory medication. It is even eight times more potent than the famous medication prednisone in animal models.
The exact mechanism of action and clinical effect is believed to occur due to its effect as a glucocorticoid receptor agonist. This leads to interaction and alteration of expression of genes related to inflammation.
Specifically, there is a decreased expression of the pro-inflammatory cytokines and an increase in anti-inflammatory mediators. It also reduces the migration of different cell types like neutrophils, macrophages, lymphocytes, and mast cells.
Overall, triamcinolone acetonide leads to decreased severity of inflammation and, as a result, is used in inflammatory diseases.
• Brand names
Triamcinolone topical
Kenalog
Triderm
Trianex
Cinolar
Triamcinolone ophthalmic
Triavaris
Triesence
Triamcinolone nasal
Nasacort
Nasacort Allergy 24HR\
Nasacort AQ
Nasacort HFA
Dental paste
KENALOG IN ORABASE
ORALONE
Nystatin and triamcinolone acetonide cream
Using triamcinolone can be helpful in fungal infections when combined with nystatin. The nystatin component of this medication will act as an antifungal, while triamcinolone acetonide is added to decrease inflammation, swelling, redness, and skin itchiness. The brand name for this medication is Nystatin and Triamcinolone Acetonide.
The cream is a smooth, soft cream that has a light yellow color. Each gram of this cream provides around 100,000 Nystatin units and 1 mg triamcinolone acetonide. The cream is supplied in 15-gram, 30-gram, and 60-grams tubes.
Triamcinolone acetonide forms and specifications
• triamcinolone acetonide cream 0.1%
Triamcinolone acetonide cream 0.1% is the most commonly used form. It contains 1 mg of the medication in a cream base that consists of different compositions like glyceryl monostearate, isopropyl palmitate, polysorbate-80, cetyl alcohol, cetyl esters wax and purified water.
• triamcinolone acetonide ointment
The ointment form of triamcinolone acetonide is used topically to treat inflammatory skin and oral lesions. It is available as 0.025% and 0.1% of triamcinolone in a base containing white petrolatum and mineral oil. The 0.025% form is present as 80-gram tubes, while the 0.1% form is present as either 15 gram and 80-gram tubes or 1 Lb jars. It is stored at a controlled room temperature of 15°-30°C.
• triamcinolone acetonide lotion
Triamcinolone acetonide lotion is available as a lotion. A lotion is different from creams in that it has higher water content. Triamcinolone acetonide lotion is present as 0.025% and 0.1%, and it is commonly used to treat inflammatory skin diseases.
Apply the 0.025% form to the affected area two to four times daily, while the 0.01% is used two to three times daily.
• triamcinolone acetonide injection
Triamcinolone acetonide is also available as injections. It is used to treat different conditions that lead to systemic effects caused by inflammation like, for instance, gout, arthritis, certain lung diseases, and some autoimmune disorders. The drug can lead to specific side effects related to suppressed immune response.
• triamcinolone acetonide nasal spray
Triamcinolone nasal spray is used to control runny nose, sneezing, and allergies. It also helps in the watery eye caused by allergies. However, the drug shouldn’t be used to treat sneezing or runny nose caused by the common cold. This is because triamcinolone works by inhibiting the release of specific chemicals, known as histamine, produced in allergies, not infections.
triamcinolone acetonide cream uses
• triamcinolone acetonide cream for poison ivy
Poising ivy is an allergic reaction that leads to the appearance of a very characteristic rash. This happens in people who have an allergy to an oily resin called urushiol present in stems, leaves, and roots of poison ivy.
Poison ivy rash can lead to itching, swelling, and blisters. Triamcinolone acetonide is used to treat these symptoms by decreasing inflammation.
• triamcinolone acetonide cream for acne
Triamcinolone acetonide cream is not commonly used for acne. Although it may sound intuitive to use an anti-inflammatory cream in acne, other common effective drugs work much better than triamcinolone acetonide cream.
• triamcinolone acetonide cream for yeast infection
Triamcinolone acetonide cream can be combined with nystatin (an antifungal medication) to reduce discomfort and inflammation from the fungal infection (yeast infections). When both drugs are combined, this combination is known as Nystatin and Triamcinolone Acetonide, and it is very commonly used in these cases.
Triamcinolone acetonide side effects
You should seek medical advice about side effects because they can vary depending on the method of administration. Side effects that may occur include:
Burning
Itching
Change in skin color
Unwanted hair growth
Red or white bumps on the skin
Drying of the skin
Blurred vision, muscle weakness, or mood changes ( only in systemic use)
Call your doctor for medical advice in case of the presence of severe rash near the site of application or in case of serious side effects. Weight gain is unlikely to occur if the medicine is used topical use. Weight gain more commonly occurs in systemic corticosteroids. Drug interactions are rare in topical use.
Where to buy triamcinolone acetonide cream
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FAQ
what is triamcinolone acetonide cream used to treat?
Triamcinolone acetonide is a topical corticosteroid used to treat several inflammatory skin disorders like psoriasis and contact dermatitis. In general, you can use this medication to decrease dryness, crusting, and redness caused by inflammatory skin disorder.
It is also combined with nystatin to treat fungal skin infections. It is also available as a dental paste to treat mouth ulcers, excruciating mouth ulcers. Using triamcinolone nasally can also treat allergic rhinitis.
How long should I use triamcinolone acetonide?
An experienced physician should determine the length you should use triamcinolone and the dose. The use may vary from person to person, depending on the reason behind using it. You should call your doctor to determine how long you should use it. This will help avoid any side effects that may occur
Is triamcinolone acetonide cream the same as hydrocortisone?
No, they aren’t the same. Both drugs are synthetic corticosteroids which means that they are manufactured. However, they can be used to treat various inflammatory skin disorders since they are synthetic corticosteroids and have anti-inflammatory effects. Moreover, triamcinolone is five times more potent than hydrocortisone. They both share the same side effects and uses
Is triamcinolone acetonide an antifungal cream?
Triamcinolone acetonide by itself doesn’t act as an antifungal. However, it is combined with nystatin (antifungal medication) to treat some fungal skin infections. This combination (both drugs) is known as Nystatin and Triamcinolone Acetonide, and it is commonly used in fungal skin infections.
References
1、https://pubchem.ncbi.nlm.nih.gov/compound/Triamcinolone#:~:text=Triamcinolone%20is%20a%20C21%2Dsteroid,to%20treat%20various%20skin%20infections.
2、https://www.rxlist.com/nystatin-and-triamcinolone-acetonide-drug.htm#description
3、https://www.rxlist.com/triamcinolone-cream-drug.htm
4、https://www.rxlist.com/triamcinolone-ointment-drug.htm#indications
5、https://www.rxlist.com/triamcinolone-lotion-drug.htm#indications
6、 https://www.webmd.com/drugs/2/drug-9/triamcinolone-acetonide-injection/details
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