Sandoz today announces that it has signed an agreement with Shionogi & Co Ltd for commercialization of Rizmoic® (naldemedine) in the key European markets of Germany, the UK and the Netherlands, plus right of first refusal for certain other European markets.
Rizmoic®, a once-daily 200-microgram oral tablet discovered and developed by Shionogi, is an innovative medicine indicated to treat opioid induced constipation (OIC) in adult patients previously treated with a laxative. Shionogi announced on February 22, 2019 that it had received EU marketing authorization for Rizmoic®.
OIC is a prevalent and distressing side-effect of opioid therapy that does not respond reliably to treatment with conventional laxatives[1].
"Our purpose at Sandoz is to pioneer access by focusing increasingly on differentiated, value-added therapeutics that can make a real difference when it comes to meeting unmet medical needs," said Francesco Balestrieri, Sandoz CEO a.i.
He added: "This agreement represents a significant step forward for that strategy and for patients in Europe, reinforcing our long-term commitment to building a leading anti-pain franchise and complementing our portfolio dedicated to minimizing the side-effects of opioid use."
Sandoz has a strong presence in the European market for anti-pain therapeutics, as well as a complementary strategic focus on innovative therapeutic alternatives to combat opioid dependency. This year saw the US launch of two such products, including the first prescription digital therapeutic in this field.
Under the terms of the agreement, Sandoz will be responsible for commercializing Rizmoic® in Germany, the UK and the Netherlands and Shionogi will be responsible for its manufacturing and development. Further details of the deal are not being disclosed.
About Rizmoic® (naldemedine)
Naldemedine is a peripherally-acting mu-opioid receptor antagonist (PAMORA) that has been developed by Shionogi as a once-daily treatment for OIC. The efficacy and safety of naldemedine have been evaluated in randomized, double-blind, placebo-controlled studies in adult OIC patients in different countries who have chronic non-cancer pain or cancer. OIC is a change in bowel movements caused by opioid therapy that is characterized by any of the following: reduced bowel movement frequency, development or worsening of straining to pass bowel movements, a sense of incomplete rectal evacuation, or harder stool consistency [2].
Disclaimer
This press release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements can generally be identified by words such as "drives," "portfolio," "commitment," "purpose," "pioneer," "focusing," "can," "step forward," "strategy," "commitment," "launch," "will," "may," "potential," or similar terms, or by express or implied discussions regarding potential launches, marketing clearances and authorizations, new indications or labeling for naldemedine or the other products described in this press release, or regarding potential future revenues from such products or the collaboration with Shionogi. Such forward-looking statements are based on our current beliefs and expectations regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. You should not place undue reliance on these statements. There is no guarantee that the collaboration with Shionogi will achieve any or all of its intended goals and objectives, or within any particular time frame. Neither can there be any guarantee that naldemedine will be successfully launched in the defined European markets, in the expected time frame, or at all. Nor can there be any guarantee that naldemedine, the other products described in this press release, or the collaboration with Shionogi will be commercially successful in the future. In particular, our expectations regarding such produ...
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