Introduction
The oral Liquid dosage line is a set of equipment, machines, and instruments used in the manufacturing, material transfer, filling, and packaging of the liquid pharma dosage in finished form. Raw material enters from one side of the line and passes through different phases, processes, and equipment. It changes its product shape and property until it converts itself into the final finished form from the end of the line.
The entire operations, such as manufacturing, filling, and packing, are carried out in a single facility without transferring material from one facility or area to another. The utilities, power, and other necessities are provided at a single location.
Components of Oral Dosage Line
Following are some important components of oral dosage line
Vessels
Vessels are metallic, circular-shaped containers used for containing liquids. They are used in the manufacturing section to manufacture a liquid pharma product. Depending upon the product and process requirements, they can include additional accessories such as a temperature sensor, level sensor, mixer with motor, and nozzles for water or another liquid solvent.
Vessels are made up of stainless steel material to prevent corrosion and to affect the liquid product. There are two types of stainless steel used for manufacturing vessels – 304 & 316L
SS316L is used for manufacturing parts that come in direct contact with the product, such as internal parts and mixers. While 304 is used to manufacture parts of the vessel that do not come in direct contact with a product, such as a vessel exterior.
In a liquid section, there can be different types of vessels. Each type has a dedicated function that can be used for specific purposes and applications. There are two common types of vessels used in oral liquid manufacturing – Manufacturing and Storage vessels.
Manufacturing Vessel
Manufacturing vessels are used to manufacture the liquid product. They contain accessories, systems, and functions typically used during product manufacturing.
For example, they contain a mixer powered by a motor to mix the solution. Mixer is used to mixing the water/solvent with raw material. Other accessories can include
· Temperature sensor to monitor the temperature of product
· Level sensor for mentoring the liquid level.
· Sight glass to manually observe the product condition
After manufacturing the product in manufacturing vessels, the liquid is transferred to storage vessels for storing liquid product for further processing.
Storage Vessel
Storage vessels are used to store liquid products after manufacturing from the manufacturing vessel. They are used as a transition before filling into the containers. Its purpose is to free the manufacturing vessel for further product manufacturing. Storage vessels are often superficial and commonly do not contain accessories other than the basic ones.
Transfer System
A transfer system directly transfers the liquid from the storage vessels into the filling machine. It consists of a network of pipes interconnected to different vessels and filling machines. A pump transfers liquid from vessels by connecting the appropriate piping network.
The transfer system is interconnected to the level monitor in the filling machine. If the tank in the filling machine is empty or below the threshold level, the pump is activated to fill the tank. When the level is enough at the threshold level, the pump stops.
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