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Home Industry Insights Products Guide
Metformin HCl API Market Size and Manufacturers in China

Metformin HCl API Market Size and Manufacturers in China

by PharmaSources

July 13, 2021

What is Metformin HCl

Metformin HCl is an antidiabetic and anti-hyperglycemic drug of the biguanide class. Common brand names include Glucophage and Glucophage XR.

Metformin HCl Forms and Specifications

Metformin HCl is available in an API powder 99%, immediate-release tablets, extended-release tablets, and capsules. 

Metformin HCl API Powder 99%

Metformin HCl API powder (CAS 1115-70-4) is in the form of a white crystalline powder. The specification from Chinese manufacturers Shijiazhuang Polee Pharmaceutical Co., Ltd., Dijia Pharmaceutical Group Co., Ltd., Wuhan ZY Pharmaceutical Co., Ltd., Shouguang Fukang Pharmaceutical Co., Ltd., and Hebei Tiancheng Pharmaceutical Co., Ltd. is 99% min.

Metformin HCl Tablets

Metformin HCl is available in generic and brand immediate-release and extended-release tablets. Metformin immediate-release tablets come in 500 mg, 850 mg, and 1000 mg strengths. The brand name is Glucophage. Metformin extended-release tablets come in 500 mg and 750 mg strengths. The brand name is Glucophage XR.

Metformin HCl Capsules

Metformin HCl is available in enteric capsules in some countries. 

Berberine Vs. Metformin

In 1988, berberine, a Chinese herb, was recognized for exerting hypoglycemic effects while being used to treat diarrhea in diabetic Chinese patients and has been used to treat diabetes by many doctors in China since then (Yin et al.). There are many reports in Chinese literature regarding the hypoglycemic effect of berberine, but most of the studies and experiments were not well-controlled nor well-designed (Yin et al.). 

Although metformin is the first-line drug for treating diabetes, experimental studies show that berberine is promising, and both drugs may have similar mechanisms of action despite their structure differences (Wang et al.).

Metformin HCl API Powder

Mechanism of Action of Metformin HCl

According to DrugBank, metformin HCl exerts its anti-hyperglycemic effect by decreasing glucose production in the liver and decreasing the absorption of glucose in the intestines while increasing insulin sensitivity by increasing peripheral uptake and use of glucose.

Metformin HCl API Manufacturing Process

To produce safe and high-quality API in accordance with Good Manufacturing Practice, metformin HCl is manufactured by the “reaction of dimethylamine hydrochloride with dicyandiamide to yield base” (PubChem). Impurities are then extracted until metformin HCl API powder reaches 99% purity.

Uses of Metformin HCl

Metformin HCl is an anti-diabetic drug from the biguanide class used to treat type 2 diabetes, controlling high blood glucose levels. It can also help with weight loss and may even help with anti-aging and longevity (Soukas et al.).   

Metformin HCl Dosage

For treatment of type 2 diabetes, the initial dose for the immediate-release tablets is 500 mg by mouth every 12 hours or 850 mg by mouth daily with meals. The maintenance dose is 1550 mg – 2550 mg daily in divided doses every 8 – 12 hours; not to exceed 2500 mg/day.

For the extended-release tablets, the dose is 500 mg by mouth daily with dinner, not to exceed 2000 mg/day. 

Side Effects of Metformin HCl

The most common side effects of metformin are generally gastrointestinal-related such as diarrhea, flatulence, and nausea. It can also cause hypoglycemia and dizziness.

You can find Chinese manufacturers of Metformin HCl API Powder and the bulk price on PharmaSources

Metformin HCl API Manufacturers in China:

Shijiazhuang Polee Pharmaceutical Co., Ltd., Dijia Pharmaceutical Group Co., Ltd., Wuhan ZY Pharmaceutical Co., Ltd., Shouguang Fukang Pharmaceutical Co., Ltd., and Hebei Tiancheng Pharmaceutical Co., Ltd. manufacture metformin HCl API powder 99% in bulk. If you need a price quote, certificate of analysis (COA), or a detailed specification sheet, please visit these suppliers of metformin HCl API on www.pharmasources.com.  

Shijiazhuang Polee Pharmaceutical Co., Ltd.

Established in 2006, Shijiazhuang Polee Pharmaceutical Co., Ltd. manufacturers API and pharmaceutical intermediates with advanced equipment. They are modern and advanced with a research center, production base, and sales department. They manufacture in accordance with Good Manufacturing Practice. 

To learn more about the services and products provided by Shijiazhuang Polee Pharmaceutical Co., Ltd., visit www.pharmasources.com. 

Dijia Pharmaceutical Group Co., Ltd.

Established in 2005, Dijia Pharmaceutical Group Co., Ltd. is growing in the API and manufacturing business. They provide high-quality products while complying with USP, EP, JP, CP, and Good Manufacturing Practice for most of their products. 

For more information about Dijia Pharamceutical Group Co., Ltd. and the services and products they provide, visit www.pharmasources.com. 

Wuhan ZY Pharmaceutical Co., Ltd.

Wuhan ZY Pharmaceutical Co., Ltd. has become part of the Chinese pharmaceutical industry, instilling trust into their customers since its establishment in 2010. They manufacture high-quality products while focusing on the health and well-being of society. They are a leader of development and manufacturing of APIs and finished dosage forms, making drug research and development a priority amongst cardiovascular, digestion, anti-fungal, liver disease, and respiratory disease topics.

To learn more about Wuhan ZY Pharmaceutical Co., Ltd. and their products and services, visit www.pharmasources.com. 

Shouguang Fukang Pharmaceutical Co., Ltd.

Shouguang Fukang Pharmaceutical Co., Ltd. was established in 1993, earning more than 25 years of pharmaceutical manufacturing experience. Ranked #42 among China’s pharmaceutical industry, Shouguang Fukang Pharmaceutical Co., Ltd. uses advanced research and technology to develop new drugs. They abide by quality assurance and control systems, having ISO9001/14001 and OHSAS18001 certifications. Five of their APIs, including metformin HCl API, have passed inspection by USFDA. In addition, they hold certification from the EDQM. Their products are sold in 26 provinces and exported to more than 60 countries. Based on integrity and trust, Shouguang Fukang Pharmaceutical Co., Ltd. welcomes national and international cooperation and partnerships.

For more information about Shouguang Fukang Pharmaceutical Co., Ltd, and their products and services, visit www.pharmasources.com. 

Hebei Tiancheng Pharmaceutical Co., Ltd. 

Hebei Tiancheng Pharmaceutical Co., Ltd. was established in 1970, gaining 50 years of pharmaceutical experience. Their products are sold domestically as well as in Central Asia, Southeast Asia, South America, Africa, and other countries. They are always looking for new partners to help contribute to the health of humans.

To learn more about Heibei Tiancheng Pharmaceutical Co., Ltd. and the products and services they provide, visit www.pharmasources.com. 

Find Suppliers with PharmaSources

If you are looking for the highest quality products that are manufactured by the most experienced pharmaceutical suppliers and medical product suppliers, visit pharmasources.com. PharmaSources is a platform that has broadened their services to more than 900,000 active members across 211 countries and regions. Displaying more than 1,600,000 products in 30 major categories, their mission is “to connect global buyers with quality suppliers and facilitate easy trade of the pharmaceutical industry” (PharmaSources).

FAQ

What is the market size of metformin HCl?

  • According to FOX 40, the global market for metformin is predicted to grow at a CAGR of 5.5% to reach USD 405.6 million by 2027.

When is the best time to take metformin HCl?

  • The best time to take metformin HCl is with meals. 

References:

  1. Company Profile of Dijia Pharmaceutical Group Co., Ltd. PharmaSources. https://www.pharmasources.com/company-profile/dijia-pharmaceutical-group-co-ltd-userId-897.html. Accessed June 24, 2021.

  2. Company Profile of Hebei Tiancheng Pharmaceutical Co., Ltd. PharmaSources. https://www.pharmasources.com/company-profile/hebei-tiancheng-pharmaceutical-co-ltd-userId-12367.html. Accessed June 24, 2021.

  3. Company Profile of Shijiazhuang Polee Pharmaceutical Co., Ltd. PharmaSources. https://www.pharmasources.com/company-profile/shijiazhuang-polee-pharmaceutical-co-ltd-userId-21552.html. Accessed June 24, 2021.

  4. Company Profile of Shouguang Fukang Pharmaceutical Co., Ltd. PharmaSources. https://www.pharmasources.com/company-profile/shouguang-fukang-pharmaceutical-co-ltd-userId-324.html. Accessed June 24, 2021.

  5. Company Profile of Wuhan ZY Pharmaceutical Group Co., Ltd. PharmaSources. https://www.pharmasources.com/company-profile/wuhan-zy-pharmaceutical-co-ltd-userId-68300.html. Accessed June 24, 2021.

  6. Metformin. DrugBank. https://go.drugbank.com/drugs/DB00331. Accessed June 23, 2021.

  7. Metformin ER (Glucophage XR). GoodRx. https://www.goodrx.com/metformin-er-glucophage-xr. Accessed June 23, 2021.

  8. Metformin. GoodRx. https://www.goodrx.com/metformin. Accessed June 23, 2021.

  9. Metformin Hydrochloride Enteric Capsules. China Associate Pharmaceutical Co., Ltd. http://www.zlzy.com/en_business_show18.html. Accessed June 23, 2021.

  10. Metformin Hydrochloride Market Size with Significant CAGR of 5.5%, Analysis by Competitive Landscape, Brand Players Analysis, Trends and Demand Status with Global Share Forecast Research to 2021-2027. FOX 40. https://www.wicz.com/story/43667376/metformin-hydrochloride-market-size-with-significant-cagr-of-55-analysis-by-competitive-landscape-brand-players-analysis-trends-and-demand-status. April 14, 2021. Accessed June 23, 2021.

  11. Metformin (Rx). Medscape. https://reference.medscape.com/drug/glucophage-metformin-342717. Accessed June 24, 2021.

  12. National Center for Biotechnology Information. "PubChem Compound Summary for CID 14219, Metformin hydrochloride" PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/Metformin-hydrochloride. Accessed June 24, 2021.

  13. Soukas, Alexander A et al. “Metformin as Anti-Aging Therapy: Is It for Everyone?.” Trends in endocrinology and metabolism: TEM vol. 30,10 (2019): 745-755. 

  14. Wang, Haoran et al. “Metformin and berberine, two versatile drugs in treatment of common metabolic diseases.” Oncotarget vol. 9,11 10135-10146. 11 Sep. 2017.

  15. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712-717. 

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