As a high burden in the world, hepatocellular carcinoma (HCC) mainly occurs in HBV, HCV and alcoholic liver cirrhosis patients. The new cases reach nearly 750,000 ever year in the world[1]. HCC belongs to a rare disease in countries or regions such as Europe and the U.S., however, in Asia, especially China, HCC has a high incidence with a 5-year survival rate of only 11%[2].
Opdivo kicked off the era of HCC immunotherapies in the world, and AiRuiKa’s taking the lead in receiving the approval for HCC indication in China was an important milestone!
Major First-line/Second-line Therapies for Advanced HCC[2].
![Major First-line/Second-line Therapies for Advanced HCC[2].](https://cimg.cphi.cn/img_Cphi_cn/news/2020_03/Mimg_2003181024718892.png)
The era of multikinase inhibitors: sorafenib and lenvatinib become the first-line standard therapies of HCC
Sorafenib was the first drug approved as the first-line therapy in HCC in 2007: it could reduce the death risk of patients by 31%.
Source: Sorafenib prescribing-information
Lenvatinib showed non-inferiority vs sorafenib in the overall survival (OS): it was approved as a first-line therapy in HCC in 2018.
Source: Lenvatinib prescribing-information
Donafenib showed superiority vs sorafenib: it is the first small molecule drug superior to sorafenib in recent 12 years.
Donafenib was announced important clinical progress on Jan. 1, 2020 that the CTR20160184 registered phase III clinical trial of first-line treatment of advanced HCC (trial code ZGDH3, CTR20160184) was successful; in inoperable or metastatic advanced HCC patients who had not received systemic treatment, the median overall survival (mOS) of the donafenib group was significantly better than the controlled sorafenib group and reached a statistically significant difference and an extension of clinical significance. It is the first small molecule drug with the OS superior to sorafenib in recent 12 years! If you are looking for healthcare supply companies offering this kind of drug, then Pharmasources would be your best choice.
The era of tumor immunotherapies: anti-PD-(L)1 monoclonal antibodies bring breakthroughs to HCC treatment
Opdivo was approved as a second-line therapy of HCC upon CheckMate-040 in 2017. It was the first anti-PD-(L)1 antibody approved for this indication, marking the start of the era of tumor immunotherapies of HCC!
Source: Opdivo prescribing-information
Keytruda was approved as a second-line therapy in HCC upon KEYNOTE-224 in 2018 to become the world’s 2nd anti-PD-(L)1 antibody approved for this indication.
Source: Keytruda prescribing-information
Tumor immunotherapies: Tecentriq + Avastin to become a breakthrough in the HCC first-line therapy in recent 12 years
Oct. 21, 2019 was a memorable day!
Roche announced milestone research progress: according to the data of IMbrave150, compared to sorafenib, Tecentriq + Avastin could bring significant OS and progression-free survival benefits to unresectable HCC patients and reduce the death risk of HCC patients by 42%, showing superiority!!!
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