Exogenous lung surfactant of choice DPPC is a kind of phospholipid product? Dipalmityl phosphatidylcholine (DPPC) is a synthetic phospholipid widely used in the field of pharmaceutical preparations as a kind of medicinal raw materials. This article follows Xiaobian to understand it
Dipalmityl phosphatidylcholine (for injection)
Chemical name: 1, 2-dipalmitoyl-Sn - glycerol -3- phosphate choline
Common English name: DPPC
CAS no. : 63-89-8
DMF number: 19820
Grade: medicinal injection grade
Registration number: F20180000192
Molecular weight; 734.06
Molecular formula: C40H80NO8P
Preservation conditions: -20℃ below, shading sealed
1, DPPC as the drug substance
Pulmonary surfactants, which mimic pulmonary surfactants, can significantly reduce neonatal mortality in neonatal respiratory distress syndrome. In addition to natural pulmonary surfactants derived from pig or bovine lung, semi-synthetic or total synthetic pulmonary surfactants need to be added with DPPC as the main active substance. Surfactant-TA is a semisynthetic lung Surfactant which has been used in clinic earlier. It is composed of DPPC, triglyceride and palmitic acid in bovine lung extract.
Exosurf is a fully synthetic lung surfactant produced by Burroughs Wellcome Company in the United States. Its composition is DPPC:16 alkanol: tetrabutylphenolic =13.5:1.5:1. Compared with the extraction source, the fully synthetic pulmonary surfactant has the advantages of high purity, good stability, sterility and no allergy to children. At present, there is no synthetic pulmonary surfactant registered in China.
2. DPPC as excipients
2.1 Application to thermosensitive liposomes
DPPC phase transition temperature is 41℃, so it is an essential phospholipid for the preparation of temperature-sensitive liposomes. Thermodox, a thermosensitive liposome developed by Celsion Company, contains 90% DPPC in its membrane components. It has been proved by clinical studies that Thermodox can increase the concentration of adriamycin in Liu site by 10 times through combined radiofrequency ablation technology. Thus, the problem of slow drug release in liposome Liu was solved, making the drug more targeted to Liu. Themodox is now doing international multi-center Ⅲ clinical trials in China.
2.2 Ultrasonic contrast agent applied to microbubbles
Because of its strong effect of reducing the gas-liquid surface tension, DPPC is also used in the coating material of micro-bubble ultrasonic contrast agent, which can make the bubble not easy to burst and enhance the stability. For example, perfluoropropane lipid microsphere suspension Definity contains DPPC 0.401mg/ mL in its envelope material.
2.3 other
As a common synthetic phospholipid, DPPC can also be widely used in drug complexes, lipid microspheres and other special drug delivery systems.
As an active ingredient, it is mainly used as lung surfactant. As excipients, can be used in liposomes or temperature-sensitive liposomes, as well as special lipid microspheres, drug compounds and other pharmaceutical preparations, so multifunctional DPPC, interested in you might as well try.
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