Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) ("Corbus" or the "Company") today announced the appointment of Craig Millian as Chief Commercial Officer, effective February 28, 2019. Mr. Millian will develop and drive U.S. and global marketing and commercialization strategies at Corbus, with an initial focus on lenabasum. He will serve on the senior management team and report to Yuval Cohen, Ph.D., Chief Executive Officer.
Mr. Millian brings 25 years of experience leading commercial organizations and a successful track record building pharmaceutical brands during all stages of development and commercialization. He most recently served as Senior VP and Head of U.S. Neurology and Immunology at EMD Serono, Inc and prior to that served as VP of Commercial at Vertex Pharmaceuticals Inc. Prior to Vertex, he held commercial leadership roles at Pfizer Inc. and Sanofi.
"As lenabasum moves toward the completion of key registrational studies in 2020, we are delighted to welcome Craig to Corbus," stated Dr. Cohen "He will formulate our go-to-market commercial and marketing strategy and assemble and lead the right team to execute it. Throughout his career, Craig has led the development and execution of numerous commercial strategies and has built and retained high-impact teams. His proven excellence in developing commercial strategies ahead of product launch will help prepare Corbus for potential FDA approval and launch of lenabasum in 2021."
"I am proud to join Corbus at this exciting time," said Craig Millian, Chief Commercial Officer of Corbus. "I believe Corbus is at the forefront of harnessing the endocannabinoid system to produce innovative therapies for inflammatory and fibrotic diseases. I look forward to leveraging my commercial and brand experience to build and lead the Company’s global commercialization strategies."
About Craig Millian
Prior to joining Corbus, Mr. Millian held various commercial leadership positions at EMD Serono, including Senior Vice President, Head of U.S. Fertility and Endocrinology, and Senior Vice President, Head of U.S. Neurology and Immunology. In these roles, he was responsible for leading the strategic direction and driving operating results for these franchises in the U.S. He oversaw key areas of the business, including sales, marketing and patient support services. Previously, Mr. Millian served as Vice President, Commercial at Vertex, where he helped design and build the commercial infrastructure, organizational capabilities and go-to-market plans in advance of launching the Vertex product pipeline. Prior to Vertex, he held commercial leadership roles at Pfizer Inc. and Sanofi. Mr. Millian holds an MBA from New York University and a degree in Finance from the University of Pennsylvania.
About Lenabasum
Lenabasum is a rationally-designed, oral, small molecule that selectively binds as an agonist to the cannabinoid receptor type 2 (CB2). CB2 is preferentially expressed on activated immune cells, fibroblasts, muscle cells, and endothelial cells. In both animal and human studies conducted to-date, lenabasum has induced the production of Specialized Pro-resolving lipid Mediators ("SPMs") that activate endogenous pathways which resolve inflammation and speed bacterial clearance without immunosuppression. Lenabasum is also believed to have a direct effect on fibroblasts to limit production of fibrogenic growth factors and extracellular connective tissue that lead to tissue fibrosis (scarring). Data from animal models and human clinical studies suggest that lenabasum can reduce expression of genes and proteins involved in inflammation and fibrosis. Lenabasum has demonstrated promising activity in animal models of skin and lung inflammation and fibrosis in systemic sclerosis (SSc). Lenabasum is also active in animal models of lung infection and inflammation in cystic fibrosis and joint inflammation and scarring in rheumatoid arthritis.
Lenabasum has demonstrated favorable safety and tolerability profiles in clinical studies to date. Lenabasum improved multiple physician-assessed and patient-reported efficacy outcomes in Phase 2 studies in patients with diffuse cutaneous SSc and skin-predominant dermatomyositis. Lenabasum also reduced pulmonary exacerbations in a Phase 2 cystic fibrosis study. Additional clinical studies are being conducted and/or planned to confirm these r...
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