Clarivate Plc (NYSE: CLVT), a global leader in providing trusted information and insights to accelerate the pace of innovation, today announced the release of its annual Drugs to Watch™ report, identifying drugs entering the market or launching key indications in 2022 which are predicted to achieve blockbuster status by 2026. Leveraging Clarivate data and insights, analysts identified seven late-stage experimental treatments that they forecast will deliver annual sales of more than $1 billion within five years. These treatments span a remarkably diverse set of therapeutic areas, from conditions like Alzheimer's disease (AD), asthma and type 2 diabetes mellitus (T2DM), which afflict tens of millions of patients worldwide, to rare diseases, such as transthyretin amyloidosis (ATTR), among others.
The report also offers an in-depth analysis of key COVID-19 vaccines and therapies along with key therapeutic development areas to watch, such as cell and gene therapies, CRISPR, drug discovery driven by artificial intelligence and machine learning, RNA and targeted cancer therapies. In addition, the report examines blockbuster drugs and biologics facing generic competition due to U.S. patent expirys in 2022.
Navigating the global healthcare landscape is increasingly complex, and discovering, developing and commercializing successful treatments that change patient lives can be challenging, especially during today's unprecedented times. The Drugs to Watch report highlights experimental treatments with great promise to realize improved patient outcomes and efforts to finance the next generation of innovative medicines. Through adaptation, improvisation and crowdsourcing solutions, the companies behind these promising treatments are advancing a broad array of innovative treatment candidates – leveraging deep expertise in their relevant therapeutic areas and long-term strategies for pursuing therapeutic solutions for these conditions.
Among new drugs and biologics that have either won approval or are poised to do, Clarivate has identified seven treatments that it believes are likely to achieve blockbuster status in the next five years. The 2022 Drugs to Watch, include:
Adagrasib, developed by Mirati Therapeutics Inc and Zai Lab Limited - This long-awaited, targeted treatment will likely be the first such treatment option in patients with colorectal cancer (CRC) with the KRASG12C mutation, who historically have had very few treatment options. The common variants of the KRAS oncoprotein are traditionally considered intractable drug targets which makes the forecasted entry of a KRAS inhibitor for patients with mutation-positive solid tumors so monumental.
Faricimab, developed by Roche and Chugai Pharmaceutical - For patients with diabetic macular edema (DME) or wet age-related macular degeneration (AMD), faricimab offers a potentially more convenient option as it will be administered less frequently, on average, than the standard of care. As the first bispecific antibody to launch in ophthalmology, it also has the potential to be more efficacious than current standard of care, although data so far indicates it is non-inferior to the standard of care. Faricimab is the first dual VEGF/Ang-2 inhibitor to treat DME and wet AMD (and the first bispecific MAb in the ophthalmology therapeutic area overall).
Lecanemab, developed by Eisai Co Ltd and Biogen Inc, and donanemab, from Eli Lilly and Company - In this underserved market, anti-Aβ MAbs lecanemab and donanemab are poised to follow on the heels of the U.S. FDA's landmark accelerated approval of ADUHELM for the treatment of AD. Lecanemab and donanemab could offer differentiated clinical profiles, which may be bolstered by phase 3 results that are expected to be reported beginning in late 2022. Data across clinical trials suggest that sufficient exposure to optimal doses of anti-Aβ MAb therapy could be clinically effective in early AD.
Tezepelumab, developed by Amgen and AstraZeneca - Tezepelumab is a potential game changer for patients with non-TH2 or TH2-low asthma whose asthma is not well-con...
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