Cellectis S.A. (NASDAQ: CLLS - EURONEXT GROWTH: ALCLS) (the "Company"), a clinical-stage biotechnological company employing its core proprietary technologies to develop products based on gene-editing with a portfolio of allogeneic chimeric antigen receptor (CAR) T-cells in the field of immuno-oncology and gene-edited hematopoietic stem cells ("HSC") in other therapeutic indications, featured the Cellectis Innovation Days, a company event held on May 24-28, virtually. Each episode, ranging from 16 to 48 minutes, provides an inside look into the Company's current and new product candidate pipeline, and manufacturing and technologies.
"For the past four years, in addition to the clinical development of UCART22, UCARTCS1 and UCART123, we have been pushing forward the development our new pre-clinical UCART product candidates, venturing for the first time into the solid tumor space. Additionally, we are thrilled to announce Cellectis' .HEAL genome surgery HSC platform, a new arm of Cellectis which focuses on monogenic diseases, like Sickle Cell Anemia. Lastly, we revealed our new in-house GMP manufacturing facilities in France and the United States, and unveiled our ability to move our product candidates from the bench, to bedside, with best-in-class proprietary technologies and techniques. We look forward to disclosing the potential of our newly announced capabilities over the coming years, and presenting upcoming clinical & translational data at future conferences." said Dr. André Choulika, CEO, Cellectis.
Cellectis shared overview of the Company's proprietary and partnered product pipelines
To date, more than 120 patients have been administered allogeneic CAR T cells utilizing technology developed by Cellectis, both in Cellectis-sponsored clinical trials and those of our licensing partners Allogene and Servier.
UCARTCS1 in patients with relapsed/ refractory multiple myeloma (r/r MM)
MELANI-01 is a phase 1 trial evaluating UCARTCS1 at escalating dose levels in patients with r/r MM.
Cellectis presented the preliminary translational data from the first group of patients enrolled on the MELANI-01 study at American Society of Gene and Cell Therapy's 24th annual meeting.
Early preliminary data validates CS1/SLAMF7 as a target for allogeneic CAR-T cells in multiple myeloma. UCARTCS1 expansion and persistence was observed and correlated with anti-myeloma activity, and changes in serum cytokines. The MELANI-01 trial is currently enrolling patients with protocol modifications including restarting at dose level (DL) -1, lower doses of lymphodepletion chemotherapy, which could address lymphopenia as well as result in added expansion; additional requirements for monitoring and management/prophylaxis for opportunistic infections, and cytokine release syndrome (CRS)/ hemophagocytic lymphohistiocytosis (HLH).
The MELANI-01 clinical study protocol allows for up to 18 patients to enroll in the dose escalation period and 12-30 patients in the dose expansion period of the Phase 1. The MELANI-01 trial is currently enrolling patients at DL -1, the first of 3 planned dose levels .
UCART22 in patients with relapsed or refractory B cell acute lymphoblastic leukemia (r/r B-ALL)
BALLI-01 is a phase 1 trial evaluating UCART22 at escalating dose levels in patients with r/r B-ALL.
At the 62nd American Society of Hematology Annual Meeting, in December 2020, gave a first look at the BALLI-Study:
Early preliminary data on a small number of patients who received UCART22 after Read More
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