Zika virus (ZIKV) spread rapidly worldwide since its outbreak in May 2015 and was listed as a "public health emergency of international concern" by WHO. Research of scientists has made us know deeper about the pathogenic molecular mechanism, virus structure and key pathogenic protein structure of ZIKV, however, there is still no effective drug and vaccine for ZIKV in the world. Next, I will review the ZIKV vaccine pipelines in development in the world by taking the blockbuster ZIKV drug research published on Nature by the Fudan University team as the entry point.
I. The blockbuster ZIKV drug research results published on Nature
There is still no effective drug or vaccine for the treatment of ZIKV disease, and the research projects on the virus prevention have mainly focused on the anti-Zika small molecule or antibody drugs. The Fudan University team led by Jiang Shibo and Lu Lu has recently designed and synthesized a peptide-based viral inactivator that can effectively kill ZIKV. The drug shows effect in mouse model, which is important research progress that has attracted extensive attention of the industry. The team conducted systematic analysis and research on the E protein sequence of ZIKV, and successfully designed the peptide-based candidate drug (Z2) that can inactivate ZIKV and effectively inhibit virus infection: it significantly reduced the ZIKV infection rate of placentas and fetuses in in vivo experiments and blocked the vertical transmission of ZIKV.
II. List of vaccines in development for ZIKV
WHO lifted the emergency of Zika at the end of 2016, however, long-term attention is still needed. With scientists’ research on ZIKV deepened increasingly, research has become increasingly clear about the pathogenic molecular mechanism, molecular structure, and potential drug targets, etc. of the virus, and research on the virus vaccines is also constantly advancing. The relevant virus vaccines are mainly DNA vaccine, recombinant vaccine and inactivated vaccine according to the disclosed information, and details of vaccines in development are summarized into the following table:
|
Name |
Company/Organization |
Type |
|
VRC-ZKADNA085-00-VP |
National Institutes of Health |
DNA vaccine, Phase I, clinical trial safety and immunogenicity |
|
GLS-5700 |
Inovio Pharmaceuticals, GeneOne |
DNA vaccine, Phase I, healthy volunteers and patients recruited for clinical trial, discussing safety, tolerance and immunogenicity |
|
Zika Virus Purified Inactivated Vaccine (ZPIV) |
Sanofi, GSK |
Inactivated vaccine, Phase I, into the clinical trial |
|
Zikavac |
Bharat Biotech |
Recombinant vaccine Inactivated vaccine Phase I |
|
NA |
Takeda, ASPR/BARDA |
Inactivated vaccine, BARDA planning to spend heavily to support Takeda in research of inactivated vaccine |
|
NA |
PaxVax |
NA, R&D of Zika vaccine with proprietary technology for dengue research, beg... Read More
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