1. What is Acetaminophen?
Acetaminophen is a drug used to treat moderate pain and fever in some conditions. A combination of this drug with aspirin and caffeine is often recommended as a first-line treatment in conditions like tension headaches and migraines. Acetaminophen treats a wide variety of pain problems and is generally considered safe.
The drug was first made in 1877, while some people estimate the year to be 1852. It is available under different brand names around the world in generic form and is on the World Health Organization’s List of Essential Medicines.
Definition
Acetaminophen is a compound that is a hydroxy derivative of acetanilide which is used to treat health issues related to pain and fever.
Chemical & Physical Features
IUPAC name:N-(4-hydroxyphenyl)acetamide
Synonyms: Paracetamol, 4-Acetamidophenol, Tylenol, Liquagesic, Pyrinazine, Servigesic, Alvedon
CAS: 103-90-2
Molecular formula:C8H9NO2
Molecular weight: 151.1626
Form: crystals or crystalline powder
Color:colorlessor white
Solubility: soluble in water, alcohol, methanol, acetone, ethyl acetate, dimethylformamide, ethanol, slightly soluble in ether, insoluble in pentane, benzene, and petroleum ether
Brand Names
Paracetamol
Tylenol
Panadol
Aceta
2. Acetaminophen Forms and Specifications
Acetaminophen is available in the market in different forms and specifications. The most commonly available ones are the following:
Acetaminophen API powder 99%
Acetaminophen API powder is the raw material used to commercially manufacture the drug form for treatment. The powder is available from the manufacturers that deal in raw materials for different drugs, usually from China or India. Acetaminophen API powder has a purity level of 99.9%. the high purity levels give a product that is superior to other medications. This is the highest form of purity for Acetaminophen API powder available in the market today.
Acetaminophen Tablets
Acetaminophen Tablets can be in two specifications. One is the API form that is used as a raw material to manufacture drugs. The API can be supplied in the form of tablets that has 99% purity. The other specification of the tablets is the end product tablets available under brand names like paracetamol or Tylenol, in pure or in combination with other drugs.
Acetaminophen capsules
Acetaminophen or paracetamol is also available in capsule form. Capsule forms usually are extra-strength medications used to treat serious issues or severe pain.
3. Hydrocodone Acetaminophen 5-325
It is a combination drug that puts together two powerful ingredients; an opioid called hydrocodone and a non-opioid pain reliever called acetaminophen. The opioids have an effect on the brain and change how the body reacts to pain while acetaminophen is used to reduce fevers. This drug is reserved to treat high or severe pain issues.
4. Oxycodone Acetaminophen 5-325
Oxycodone acetaminophen is a drug c typically available with a doctor's prescription. It is used in the management of severe or high pain. this drug also contains a combination of opioid called oxycodone and a non-opioid pain reliever acetaminophen. This drug works the same way the hydrocodone-acetaminophen combination works.
5. Acetaminophen vs Paracetamol
There is no difference between acetaminophen and paracetamol. These are just two different names used to describe the same drug compound.
6. Acetaminophen vs Ibuprofen
Acetaminophen is an analgesic while ibuprofen is from a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Both of these drugs decrease fever and pain. Ibuprofen however also decreases inflammation that may be present in the body and may be considered a superior pain reliever by many. However, acetaminophen is more commonly used to treat mild to moderate pain.
7. Aspirin vs Acetaminophen
Acetaminophen is an analgesic and an antipyretic while aspirin is an NSAID. Aspirin has relatively fewer side effects than paracetamol and can be used to treat pain, risk of heart attacks and strokes. Both drugs are available over the counter and are used widely.
8. Mechanism of Action of Acetaminophen
The exact mechanism of action of acetaminophen is not very well understood. It is closely related to the action of NSAIDs as it also inhibits the cyclooxygenase pathways. A theory about its mechanism of action suggests that it increase the pain threshold in the body b inhibiting the cyclooxygenase; COX-1, and COX-2. These are involved in the synthesis of prostaglandin that is responsible for pain sensations.
9. Acetaminophen Manufacturing Process
The powerful painkiller is manufactured by reacting 4-aminophenol with ethanoic anhydride, commonly called acetic anhydride. After the reaction, an amide bond forms with a by-product called ethanoic acid. After the reaction is done, the acetaminophen is isolated and then purified. The purified form is then available in the form of tablets or a white crystalline powder.
10. Acetaminophen Uses
Acetaminophen is used to relieve conditions like:
Muscle aches
Toothaches
Backaches
Pain associated with colds and sore throat
Pain from menstrual periods
Fever
Headaches
Reactions to vaccinations
11. Acetaminophen Dosage
Acetaminophen can be used in different dosages depending upon the age and condition it is being used for. Typically, it is available in dosages of 325 mg, 500 mg, 600 mg in the oral, intravenous, or suppository forms.
12. Acetaminophen Side Effects
As with every drug, acetaminophen or paracetamol has some side effects associated with its use. The side effects can range from mild to severe. Moderate side effects can be:
Rash
Hives
Shortness of breath
Cough
Dizziness
Disorientation
Skin swelling
Low levels of white and red blood cells and platelets
Serious side effects seen sometimes can be anaphylaxis, liver failure, kidney toxicity, gastrointestinal hemorrhage, laryngeal edema, hyperammonemia, and agranulocytosis.
13. Acetaminophen API price
Acetaminophen API prices differ in different parts of the world. The average rate of the acetaminophen API is USD 4500 to USD 5500/per kg.
1. Acetaminophen sodium API manufacturers in China
The acetaminophen API is being manufactured by leading Chinese industries. You can easily get the material at reasonable and wholesale prices. If you are interested in finding active pharma ingredients manufacturers and suppliers of the acetaminophen API from China, you can find them at pharmasources.com. Just go to the website and browse through hundreds of wholesalers that are selling acetaminophen in raw forms.
Here are some of the leading producers of acetaminophen API in China:
ZHEJIANG KANGLE PHARMACEUTICAL CO., LTD.
Zhejiang Kangle Pharmaceutical was formerly called Wenzhou Pharmaceutical was established in the year 1945. It researches, develops, manufactures, and sells raw materialsfor antipyretic and analgesic drugs. It is one of the leading manufacturers of acetaminophen API in China.
AnqiuLu'an Pharmaceutical Co., Ltd.
AnqiuLu'an Pharmaceutical Co. was established in 1980 and produces top-quality raw materials for drugs like acetaminophen API in China.
HumanwellPuraCap Pharmaceuticals (Wuhan) Co., Ltd
HumanwellPuraCap Pharmaceuticals (Wuhan) founded in 209 mainly works with generic drugs, prescription drugs, and over-the-counter drugs and their raw materials. It is the first plant in the city of China that is approved by the FDA and produces acetaminophen API.
FAQs
Is acetaminophen an NSAID?
No. Acetaminophen is an analgesic and is not an NSAID. However, its mechanism of action is similar to that of the NSAID class of drugs.
Is acetaminophen a blood thinner?
No, acetaminophen is not a blood thinner. It is the choice of drug given to patients suffering from pain and fever while getting oral anticoagulant therapy like warfarin.
References:
https://www.drugs.com/ingredient/acetaminophen.html
https://www.rxlist.com/consumer_acetaminophen_tylenol/drugs-condition.htm
https://pubchem.ncbi.nlm.nih.gov/compound/Acetaminophen#section=DSSTox-Substance-ID
https://go.drugbank.com/drugs/DB00316
https://www.ncbi.nlm.nih.gov/books/NBK482369/
https://pubmed.ncbi.nlm.nih.gov/24779190/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223888/
https://pubmed.ncbi.nlm.nih.gov/26572078/
https://pubmed.ncbi.nlm.nih.gov/19165309/
https://www.bloomberg.com/profile/company/KAGLEZ:CH
https://www.bloomberg.com/profile/company/ANLPCZ:CH
https://www.linkedin.com/company/humanwell-puracap-pharmaceuticals-wuhan-co-ltd/
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