Category:
Central Nervous System Drugs
CAS NO:
50700-72-6
Standard:
USP,BP,
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Basic Info
CAS Number
50700-72-6
Pharmacopoeia
USP,BP
Grade
Pharmaceutical Grade
Is Manufacturer
No
Samples Provided
NO
Product Description
GMP
AI Product Description
*The following content is generated by AI and is for reference only.
Vecuronium bromide, commonly known as Vecuronium, is a potent non-depolarizing neuromuscular blocking agent widely utilized in modern clinical anesthesia. With the chemical formula C32H54N2O4 and CAS Registry Number 81769-07-5, this compound belongs to the aminosteroid class of muscle relaxants. It functions by competitively antagonizing acetylcholine at the nicotinic receptors located on the motor endplates of skeletal muscles, thereby inducing flaccid paralysis without affecting consciousness or pain perception.
The primary application of Vecuronium is to facilitate endotracheal intubation and provide optimal surgical conditions during general anesthesia. By relaxing the diaphragm and other skeletal muscles, it allows for controlled ventilation and prevents involuntary movements that could compromise delicate surgical procedures. Clinicians favor this agent due to its intermediate duration of action, which typically ranges from 25 to 35 minutes following an intravenous bolus dose. This profile makes it highly suitable for both short and moderately long operations where rapid recovery is desired post-procedure.
Unlike some older agents, Vecuronium possesses a favorable cardiovascular stability profile, causing minimal histamine release and negligible hemodynamic fluctuations even at therapeutic doses. This safety margin is particularly beneficial for patients with compromised cardiac function or those requiring hemodynamic monitoring during surgery. The drug is metabolized primarily in the liver through hydrolysis and deacetylation, with excretion occurring via bile and urine. While it does not require reversal by anticholinesterases immediately, administration of neostigmine can effectively reverse its effects if prolonged paralysis occurs.
Despite the emergence of newer agents like rocuronium, Vecuronium remains a cornerstone in anesthetic practice globally. Its reliability, predictable pharmacokinetics, and low side-effect burden ensure its continued relevance in operating rooms worldwide. Proper dosing and monitoring are essential to prevent residual paralysis, ensuring patient safety upon awakening. As a critical tool in airway management, Vecuronium continues to save lives by enabling precise control over respiratory mechanics during complex medical interventions.
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