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CAS NO:
2169247-39-4
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Basic Info
CAS Number
2169247-39-4
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Vardenafil, chemically known as (R)-4-[3-(2-oxo-1,2-dihydro-3-pyridinyl)phenyl]-N,N-diethyl-2-pyrrolidinecarboxamide, is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor primarily utilized in the treatment of erectile dysfunction (ED). Its molecular formula is C20H25N7O3S, and it carries the CAS Registry Number 224176-68-9. Structurally, Vardenafil belongs to the pyrazolo[4,3-d]pyrimidinone class of compounds, distinguishing it from other PDE5 inhibitors like sildenafil through its unique chemical scaffold, which contributes to its high selectivity for the PDE5 enzyme over other isoforms.
The primary mechanism of action involves inhibiting the degradation of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. By blocking PDE5, Vardenafil enhances the nitric oxide-mediated relaxation of these muscles, thereby facilitating increased blood flow into the penis during sexual stimulation. This physiological response enables men with ED to achieve and maintain an erection sufficient for satisfactory sexual activity. Clinically, Vardenafil is often prescribed when other treatments have failed or are contraindicated, offering a rapid onset of action typically within 30 to 60 minutes, with effects lasting up to four to five hours.
Beyond its standard oral tablet formulations, Vardenafil has been investigated for potential applications in pulmonary arterial hypertension due to its vasodilatory properties, although its regulatory approval remains focused on male sexual health. Common side effects include headache, flushing, nasal congestion, dyspepsia, and visual disturbances, though these are generally mild and transient. Contraindications strictly include concurrent use with nitrates or nitric oxide donors due to the risk of severe hypotension. Patients with significant cardiovascular disease, liver impairment, or those taking alpha-blockers require careful medical supervision before initiating therapy. As a prescription-only medication, Vardenafil represents a significant advancement in urological pharmacology, providing a reliable therapeutic option that improves quality of life for millions of patients worldwide by restoring normal sexual function.
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