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CAS NO:
124832-27-5
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Basic Info
CAS Number
124832-27-5
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Valacyclovir is a widely prescribed antiviral medication primarily utilized in the management of herpes virus infections. Chemically known as L-valyl ester of acyclovir, its molecular formula is C13H20N6O4, and it carries the CAS Registry Number 124832-27-9. This prodrug is designed to overcome the poor oral bioavailability associated with its active parent compound, acyclovir. Upon ingestion, valacyclovir is rapidly converted by hepatic enzymes into acyclovir, which then exerts its therapeutic effects by inhibiting viral DNA replication.
The primary clinical applications of valacyclovir include the treatment of herpes zoster (shingles), genital herpes simplex virus type 1 and type 2 infections, and cold sores (herpes labialis). It is particularly effective when administered early in the course of an outbreak, significantly reducing the duration of symptoms and accelerating lesion healing. Furthermore, long-term suppressive therapy with this agent helps prevent recurrent outbreaks in patients with frequent recurrences, thereby improving their quality of life. Recent studies also suggest its utility in reducing the risk of transmitting genital herpes to uninfected partners when used consistently.
Mechanistically, once inside infected cells, acyclovir is phosphorylated by viral thymidine kinase into acyclovir monophosphate, followed by cellular kinases converting it to the active triphosphate form. This active metabolite competitively inhibits viral DNA polymerase and incorporates into the growing viral DNA chain, causing premature termination. Because the initial phosphorylation step requires viral enzymes, the drug exhibits selective toxicity, targeting infected cells while sparing healthy host cells. Common side effects are generally mild and may include headache, nausea, or abdominal pain, though rare cases of thrombotic microangiopathy have been reported in immunocompromised individuals at high doses. Valacyclovir remains a cornerstone in modern virology for managing herpes-related conditions due to its efficacy, safety profile, and convenient dosing regimen compared to earlier alternatives.
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