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CAS NO:
217500-96-4
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Basic Info
CAS Number
217500-96-4
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Tulathromycin is a broad-spectrum, semi-synthetic macrolide antibiotic belonging to the 16-membered ring class known as thiomacrolides. Developed primarily for veterinary medicine, it has become a cornerstone treatment in livestock production for managing respiratory diseases caused by susceptible bacteria. The chemical structure of Tulathromycin features a unique thiosugar moiety attached to the lactone ring, which significantly enhances its stability and binding affinity compared to traditional macrolides like erythromycin. Its molecular formula is C54H93NO16S, and it is identified by the CAS Registry Number 208722-48-9. This compound acts by inhibiting bacterial protein synthesis; specifically, it binds reversibly to the 50S subunit of the bacterial ribosome, blocking the translocation step required for peptide chain elongation.
The primary clinical application of Tulathromycin is the treatment of bovine respiratory disease (BRD), also known as shipping fever, in cattle. It is highly effective against key pathogens such as *Mannheimia haemolytica*, *Pasteurella multocida*, and *Histophilus somni*. Additionally, it is utilized to treat chronic pneumonia in pigs caused by *Actinobacillus pleuropneumoniae* and *Haemophilus parasuis*. One of its most significant advantages is its long half-life in animal tissues, allowing for a single-dose regimen that provides therapeutic coverage for several days. This convenience reduces labor costs and minimizes stress on the animals during administration. Due to its pharmacokinetic profile, it is typically administered via subcutaneous injection or intramuscular route, depending on the specific formulation and species.
Despite its efficacy, the use of Tulathromycin is strictly regulated to prevent antimicrobial resistance. Veterinary oversight is mandatory, and withdrawal periods must be observed before meat or milk enters the human food supply. Resistance mechanisms, including efflux pumps and ribosomal methylation, have been documented, emphasizing the need for prudent stewardship. While not indicated for human use due to toxicity concerns and lack of approval by major health agencies, Tulathromycin remains an indispensable tool in modern veterinary practice for maintaining herd health and ensuring food safety through effective disease control. Its development marked a significant advancement in treating complex respiratory infections in large-scale agricultural settings.
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