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Other Specialized Reagents

Trimethyl orthoacetate

Category:

Other Specialized Reagents

CAS NO:

1445-45-0

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Asia

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Capot Chemical Co., Ltd.

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Basic Info

CAS Number

1445-45-0

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Packaging & Delivery

Packaging Specification

1kg、5kg、25kg

Product Description

Trimethyl orthoacetate、1445-45-0

AI Product Description

*The following content is generated by AI and is for reference only.

Trimethyl orthoacetate, chemically identified as 1,1,1-trimethoxyethane, is a versatile organic reagent widely utilized in synthetic chemistry and industrial applications. With the molecular formula C5H12O3 and a CAS registry number of 78-06-4, this colorless liquid possesses a distinct ether-like odor and exhibits moderate solubility in water while being fully miscible with most organic solvents. Its unique structural arrangement, featuring an acetal carbon bonded to three methoxy groups and one methyl group, renders it highly reactive toward nucleophiles under acidic conditions, making it an invaluable tool for protecting carbonyl functionalities. The primary application of trimethyl orthoacetate lies in its role as a methylating agent and a source of the ethylidene moiety in organic synthesis. It is frequently employed to convert carboxylic acids into their corresponding methyl esters or to synthesize enol ethers through condensation reactions. In pharmaceutical manufacturing, it serves as a critical intermediate for constructing complex heterocyclic compounds and various active pharmaceutical ingredients (APIs). Furthermore, its ability to act as a solvent stabilizer in polymerization processes adds to its utility in materials science, where it helps maintain reaction integrity during the production of specialized resins and coatings. Safety protocols are essential when handling this compound, as it can release methanol upon hydrolysis and may cause irritation to the skin, eyes, and respiratory tract. Proper storage in cool, dry, and well-ventilated areas away from strong acids and oxidizers is mandatory to prevent decomposition. Despite these precautions, its efficiency in facilitating diverse chemical transformations ensures its continued prominence in both laboratory research and large-scale industrial operations. As a cost-effective and reliable reagent, trimethyl orthoacetate remains a staple for chemists seeking precise control over molecular architecture in the development of new chemical entities and advanced functional materials.