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Preclinical Research Services

Tramadol

Category:

Preclinical Research Services

CAS NO:

N/A

Standard:

ChP,

Price Range:

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Main Sales Markets:

Europe,Asia,South America,Africa,Middle East

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China National Standard Pharmaceutical Co., Ltd.

Years

Show Room

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Basic Info

CAS Number

N/A

Pharmacopoeia

ChP

Grade

In-house Standards

Is Manufacturer

YES

Packaging & Delivery

Minimum Order Quantity

Any

Delivery Cycle

Negotiable

Product Description

Reference Standards &Impurity

AI Product Description

*The following content is generated by AI and is for reference only.

Tramadol is a centrally acting synthetic analgesic utilized for the management of moderate to moderately severe pain. Chemically, its molecular formula is C16H25NO2, and it is identified by the CAS Registry Number 27246-57-3. Structurally, tramadol belongs to the class of cyclohexylamines and functions as a weak opioid agonist with a unique dual mechanism of action. It acts primarily by binding to mu-opioid receptors in the central nervous system, inhibiting the reuptake of norepinephrine and serotonin, which modulates pain perception through descending inhibitory pathways. This distinct pharmacological profile allows tramadol to provide effective pain relief while potentially offering a lower risk of respiratory depression compared to traditional strong opioids, although it is not devoid of risks. The drug is widely prescribed in various formulations, including immediate-release tablets, extended-release capsules, and injectable solutions, making it versatile for both acute postoperative pain and chronic conditions such as osteoarthritis or neuropathic pain. Due to its opioid activity, tramadol is classified as a Schedule IV controlled substance in the United States and similarly regulated in many other jurisdictions, reflecting its potential for abuse, dependence, and addiction. Common side effects include nausea, dizziness, constipation, headache, and somnolence. Serious adverse reactions may involve seizures, serotonin syndrome when combined with other serotonergic agents, and respiratory depression, particularly in high doses or vulnerable populations. Clinicians must exercise caution when prescribing tramadol to patients with a history of substance use disorder, epilepsy, or those taking monoamine oxidase inhibitors. The drug undergoes hepatic metabolism via cytochrome P450 enzymes, specifically CYP2D6 and CYP3A4, which can lead to significant drug-drug interactions affecting efficacy and safety profiles. While tramadol has become a valuable tool in multimodal pain management strategies, reducing reliance on nonsteroidal anti-inflammatory drugs (NSAIDs) or stronger opioids in specific scenarios, its use requires careful patient monitoring and adherence to strict dosage guidelines to ensure therapeutic benefit while minimizing harm.