*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p><strong>Tipiracil</strong> (CAS 871264-59-0, C<sub>12</sub>H<sub>10</sub>N<sub>4</sub>O<sub>3</sub>) is a potent thymidine phosphorylase inhibitor. It is synthesized via multi-step organic reactions involving heterocyclic coupling and oxidation processes to ensure high purity for pharmaceutical formulation.</p>
<h3>Application</h3>
<ul>
<li>Combination therapy with trifluridine for metastatic colorectal cancer.</li>
<li>Used in oncology clinical trials to enhance drug bioavailability.</li>
<li>Serves as a key API in fixed-dose combination tablets.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly contraindicated during pregnancy due to teratogenic risks. Store in a cool, dry place below 25°C protected from light. Handle with PPE to prevent inhalation or skin contact of powder dust.</p>