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CAS NO:
25459-12-5
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Basic Info
CAS Number
25459-12-5
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Tinidazole is a potent nitroimidazole derivative widely recognized for its efficacy against a broad spectrum of anaerobic bacteria and protozoal infections. Chemically, it shares structural similarities with metronidazole but features an extended half-life, allowing for more convenient dosing regimens. Its molecular formula is C8H13N5O2S, and it is identified by the CAS number 19387-91-8. The compound appears as a white to pale yellow crystalline powder, practically insoluble in water but soluble in organic solvents.
The primary therapeutic applications of Tinidazole include the treatment of trichomoniasis, giardiasis, and amebiasis caused by Entamoeba histolytica. It is also highly effective in managing bacterial vaginosis and anaerobic infections such as intra-abdominal abscesses, pelvic inflammatory disease, and septicemia. Due to its long elimination half-life of approximately 12 to 14 hours, Tinidazole often permits single-dose therapy or short-course treatments, significantly improving patient compliance compared to multi-day regimens required by older antibiotics. This pharmacokinetic advantage makes it particularly valuable in resource-limited settings where adherence to complex medication schedules can be challenging.
Mechanistically, Tinidazole functions by entering microbial cells and undergoing reduction of its nitro group. This process generates toxic free radicals that damage microbial DNA, inhibiting nucleic acid synthesis and leading to cell death. While generally well-tolerated, common side effects may include nausea, metallic taste, dizziness, and headache. Patients are strictly advised to avoid alcohol consumption during treatment and for at least three days after discontinuation, as concurrent use can precipitate a disulfiram-like reaction characterized by severe flushing, vomiting, and tachycardia.
Contraindications typically include hypersensitivity to nitroimidazoles and use during the first trimester of pregnancy, although data regarding safety in later stages is evolving. It is crucial to note that while Tinidazole effectively treats active infections, it does not provide immunity against future reinfections. Overall, this drug remains a cornerstone in modern antimicrobial therapy, offering a reliable solution for difficult-to-treat parasitic and anaerobic conditions with a favorable safety profile when used according to established medical guidelines.
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