*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p><strong>Thio-modifier C6 S-S linker</strong> is a cleavable bifunctional crosslinker featuring a six-carbon spacer and a disulfide bond. It facilitates site-specific conjugation of thiols to sulfhydryl groups via stable amide or thioether bonds, enabling reversible linkage under reducing conditions.</p>
<h3>Application</h3>
<ul>
<li><strong>Antibody-Drug Conjugates (ADCs):</strong> Links cytotoxic payloads to antibodies for targeted delivery.</li>
<li><strong>Protein Labeling:</strong> Attaches fluorophores or biotin to cysteine residues in research proteins.</li>
<li><strong>Oligonucleotide Synthesis:</strong> Modifies DNA/RNA probes for hybridization studies with controlled release.</li>
</ul>
<h3>Precautions</h3>
<p>Store at -20°C under inert atmosphere to prevent premature disulfide reduction. Handle in a fume hood; avoid skin contact as it may cause irritation. Not approved for direct clinical use without rigorous formulation validation.</p>