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Basic Info
CAS Number
/
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Samples Provided
NO
Packaging & Delivery
Packaging Specification
25KG/DRUM
Product Description
BP2010
AI Product Description
*The following content is generated by AI and is for reference only.
Thiamphenicol is a broad-spectrum chloramphenicol derivative antibiotic widely utilized in veterinary medicine to treat bacterial infections in various animal species. Chemically, it belongs to the amphenicol class and functions by inhibiting bacterial protein synthesis. Its molecular formula is C12H15Cl2NO4S, and it is identified by the CAS number 15318-46-6. Unlike its predecessor, chloramphenicol, thiamphenicol does not typically cause aplastic anemia in humans, making it a safer alternative for animals, though it retains similar antimicrobial properties against both Gram-positive and Gram-negative bacteria.
The primary mechanism of action involves binding to the 50S ribosomal subunit of susceptible bacteria, thereby blocking peptide bond formation and halting protein production essential for bacterial survival. This makes it effective against pathogens such as *Escherichia coli*, *Salmonella* species, *Pasteurella multocida*, and certain strains of *Staphylococcus*. It is commonly administered orally or via injection in livestock, poultry, and aquaculture settings to combat respiratory diseases, enteric infections, and systemic conditions. In many countries, strict regulations govern its use due to potential residues in food-producing animals, ensuring that withdrawal periods are observed before meat or milk enters the human food supply chain.
While highly effective, the drug requires careful dosage management to prevent toxicity and resistance development. Overuse can lead to the emergence of resistant bacterial strains, complicating future treatment protocols. Furthermore, although rare, side effects may include gastrointestinal disturbances or temporary suppression of bone marrow function in sensitive individuals. Thiamphenicol remains a critical tool in modern veterinary practice, particularly where other antibiotics have failed or are contraindicated. Its stability in aqueous solutions allows for versatile formulation into powders, injectables, and feed additives. As global efforts focus on responsible antibiotic stewardship, thiamphenicol continues to play a vital role in maintaining animal health and productivity while balancing public safety concerns regarding drug residues.
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