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CAS NO:
144701-48-4
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Basic Info
CAS Number
144701-48-4
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Telmisartan is a potent and selective angiotensin II receptor blocker (ARB) widely utilized in the management of hypertension and cardiovascular risk reduction. Chemically, it belongs to the class of biphenyl tetrazole derivatives, distinguished by its unique pharmacokinetic profile that allows for once-daily dosing. Its molecular formula is C33H30N4O2, and it is identified by the CAS Registry Number 144701-48-4. The compound features a high lipophilicity, which facilitates rapid absorption and extensive distribution throughout the body, particularly into adipose tissue.
The primary therapeutic application of Telmisartan is the treatment of essential hypertension. By selectively blocking the binding of angiotensin II to the AT1 receptor subtype, it prevents vasoconstriction and the release of aldosterone, thereby lowering blood pressure without affecting the bradykinin system, which minimizes side effects like cough often associated with ACE inhibitors. Beyond blood pressure control, Telmisartan offers significant organ protection benefits. Clinical evidence suggests it reduces the risk of major cardiovascular events, including stroke and myocardial infarction, in patients with high cardiovascular risk who are intolerant to ACE inhibitors. Furthermore, emerging research highlights its potential metabolic advantages; unlike other ARBs, Telmisartan acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma), improving insulin sensitivity and lipid profiles. This dual mechanism makes it a valuable option for patients with comorbidities such as type 2 diabetes or metabolic syndrome. With a long half-life of approximately 24 hours, it provides sustained 24-hour blood pressure coverage, enhancing patient compliance. Available in various tablet strengths, Telmisartan remains a cornerstone therapy in modern antihypertensive regimens, offering a favorable safety profile and robust efficacy in preventing end-organ damage.
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