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CAS NO:
119714-13-5
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Basic Info
CAS Number
119714-13-5
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Tamsulosin, chemically known as (R)-5-[2-[2-(2-methoxyphenoxy)ethyl]amino]propyl]-2-methoxyphenol hydrochloride, is a highly selective alpha-1 adrenergic receptor antagonist primarily used in the treatment of benign prostatic hyperplasia (BPH). Its molecular formula is C20H29NO4·HCl, and it carries the CAS Registry Number 86345-87-7. This medication works by selectively blocking alpha-1A and alpha-1D receptors located in the smooth muscle of the prostate gland and bladder neck. By inhibiting these receptors, Tamsulosin induces relaxation of the smooth muscle tissue, thereby reducing urinary resistance and improving urine flow. Unlike non-selective alpha-blockers, Tamsulosin exhibits minimal effect on vascular smooth muscle, which significantly lowers the risk of systemic hypotension and orthostatic dizziness, making it a preferred first-line therapy for many patients.
Clinically, Tamsulosin is indicated to alleviate the lower urinary tract symptoms associated with BPH, such as hesitancy, weak stream, frequent urination, and nocturia. It does not reduce the size of the enlarged prostate but effectively manages the obstruction caused by increased muscle tone. The drug is typically administered orally once daily, usually 30 minutes after the same meal each day to ensure consistent absorption. Common side effects may include dizziness, headache, rhinitis, and abnormal ejaculation, though serious adverse events are rare when taken as prescribed. Due to its pharmacokinetic profile, Tamsulosin has a rapid onset of action, often providing symptom relief within days of initiation. While it is not a cure for BPH, it remains a cornerstone in urological practice for enhancing quality of life in men suffering from prostate enlargement. Extensive clinical trials have confirmed its safety and efficacy across diverse patient populations, establishing it as a standard of care in managing moderate to severe BPH symptoms globally.
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