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<h3>Overview</h3>
<p><strong>Tacrolimus</strong> (CAS <strong>104987-11-3</strong>) is a potent macrocyclic immunosuppressant produced via microbial fermentation of Streptomyces tsukubaensis. Its molecular formula is C<sub>44</sub>H<sub>75</sub>NO<sub>13</sub>.</p>
<h3>Application</h3>
<ul>
<li>Organ transplantation: Prophylaxis of organ rejection in kidney, liver, and heart transplants.</li>
<li>Dermatology: Topical treatment for moderate-to-severe atopic dermatitis.</li>
<li>Ophthalmology: Management of severe allergic conjunctivitis.</li>
</ul>
<h3>Precautions</h3>
<p>Strict therapeutic drug monitoring is required due to narrow therapeutic index. Store below 25°C in original packaging. Avoid exposure to light and moisture to maintain stability.</p>