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Basic Info
CAS Number
/
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Samples Provided
NO
Packaging & Delivery
Packaging Specification
25KG/DRUM
Product Description
BP/USP
AI Product Description
*The following content is generated by AI and is for reference only.
Sulphadoxine is a long-acting sulfonamide antibiotic primarily utilized in the field of tropical medicine for the prevention and treatment of malaria. Chemically, it belongs to the class of synthetic antimicrobial agents that function by inhibiting bacterial and parasitic dihydropteroate synthase, an enzyme essential for folate synthesis. This mechanism disrupts the metabolic pathways required for the replication of *Plasmodium* species, the parasites responsible for malaria, particularly when used in combination with pyrimethamine. The drug was developed to address the limitations of earlier short-acting sulfa drugs, offering a prolonged half-life that allows for less frequent dosing schedules, which is critical in remote regions with limited healthcare infrastructure.
The molecular formula of Sulphadoxine is C12H14N4O3S2, reflecting its complex structure containing two sulfur atoms and multiple nitrogen centers within its sulfonamide framework. Its unique Chemical Abstracts Service (CAS) registry number is 80-67-5, a standard identifier used globally for chemical tracking and regulatory compliance. While monotherapy has largely fallen out of favor due to rising resistance rates among *Plasmodium falciparum*, Sulphadoxine remains a cornerstone component of fixed-dose combinations, most notably SP (Sulfadoxine-Pyrimethamine). This combination therapy is widely recommended by the World Health Organization for intermittent preventive treatment in pregnancy (IPTp) and seasonal malaria chemoprevention (SMC) in children across endemic areas in sub-Saharan Africa.
Despite its efficacy, the use of Sulphadoxine requires careful monitoring due to potential adverse effects, including severe cutaneous reactions such as Stevens-Johnson syndrome and hematological abnormalities. Resistance issues continue to pose significant challenges, necessitating ongoing surveillance and the development of alternative regimens. Nevertheless, Sulphadoxine represents a vital tool in the global fight against malaria, saving countless lives where access to more expensive or complex antimalarial therapies is restricted. Its enduring presence in public health programs underscores the importance of combining cost-effective pharmacological strategies with robust epidemiological monitoring to combat this persistent infectious disease effectively.
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