Sulfobutyl Ether-β-cyclodextrin (SBE-β-CD)
CAS NO.: 182410-00-0
*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Sulfobutyl Ether-β-cyclodextrin (SBE-β-CD) is a water-soluble, anionic derivative of β-cyclodextrin synthesized via etherification with butane sultone. It enhances drug solubility and stability through host-guest complexation. <strong>Molecular Formula</strong>: C<sub>42</sub>H<sub>60</sub>O<sub>21</sub>S<sub>n</sub>; <strong>CAS No.</strong>: 92785-24-5.</p>
<h3>Application</h3>
<ul>
<li><strong>Parenteral Formulations</strong>: Solubilization of hydrophobic active pharmaceutical ingredients (APIs).</li>
<li><strong>Ophthalmic Solutions</strong>: Enhancing bioavailability of poorly soluble eye drops.</li>
<li><strong>Oral Delivery</strong>: Improving dissolution rates and reducing gastric irritation.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly monitor renal function in patients receiving high-dose parenteral injections due to potential accumulation. Store in sealed containers at controlled room temperature (20-25°C) away from moisture to prevent degradation or microbial growth.</p>