Category:
Hormones
CAS NO:
79902-63-9
Standard:
USP,BP,
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Basic Info
CAS Number
79902-63-9
Pharmacopoeia
USP,BP
Grade
Pharmaceutical Grade
Is Manufacturer
No
Samples Provided
NO
Product Description
GMP
AI Product Description
*The following content is generated by AI and is for reference only.
Simvastatin, chemically known as (1S,3R,7S,8S,8aR)-2,2-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-decahydro-1-naphthalenyl 2-methylbutanoate, is a widely prescribed pharmaceutical agent belonging to the statin class of drugs. Its molecular formula is C25H38O5, and it carries the CAS Registry Number 79902-63-9. This compound serves as a prodrug, meaning it is administered in an inactive lactone form that undergoes hydrolysis in the liver to its active beta-hydroxy acid metabolite. The primary therapeutic application of Simvastatin is the management of hypercholesterolemia and mixed dyslipidemia. It functions by competitively inhibiting HMG-CoA reductase, the rate-limiting enzyme in the cholesterol biosynthesis pathway within the liver. By blocking this enzyme, Simvastatin significantly reduces the hepatic production of low-density lipoprotein (LDL) cholesterol and triglycerides while simultaneously raising high-density lipoprotein (HDL) levels.
Beyond lipid regulation, clinical evidence supports the role of Simvastatin in reducing the risk of major cardiovascular events, including myocardial infarction, stroke, and the need for revascularization procedures in patients with coronary heart disease or diabetes. It is typically available in oral tablet formulations with varying dosages, such as 10 mg, 20 mg, 40 mg, and 80 mg, usually taken once daily in the evening due to the circadian rhythm of endogenous cholesterol synthesis. While generally well-tolerated, common side effects may include myalgia, headache, and gastrointestinal disturbances. Rare but serious adverse reactions involve rhabdomyolysis and hepatotoxicity, necessitating periodic monitoring of liver enzymes and creatine kinase levels in patients undergoing long-term therapy. As a cornerstone in preventive cardiology, Simvastatin remains a cost-effective and essential medication for global cardiovascular health management, often used in conjunction with lifestyle modifications like diet and exercise to achieve optimal lipid profiles.
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