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CAS NO:
79559-97-0
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Basic Info
CAS Number
79559-97-0
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Sertraline, chemically known as (1S-cis)-4-(3-chlorophenyl)-1,2,3,4-tetrahydro-1-methyl-N-[3,4-dichlorophenyl]-1-naphthalenemethanamine, is a widely prescribed selective serotonin reuptake inhibitor (SSRI) primarily used in the treatment of major depressive disorder, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, and social anxiety disorder. Its molecular formula is C17H17Cl2N, with a corresponding CAS registry number of 79617-96-2. The compound features a naphthalene core structure substituted with chlorine atoms at positions 3 and 4 on one phenyl ring and a methyl group on the nitrogen atom, which contributes to its high selectivity for inhibiting serotonin reuptake without significant interference with other neurotransmitter systems like dopamine or norepinephrine at therapeutic doses.
As an SSRI, Sertraline works by blocking the presynaptic transporter responsible for recycling serotonin back into nerve cells, thereby increasing the concentration of this neurotransmitter in the synaptic cleft. This mechanism helps regulate mood, anxiety, and impulse control, alleviating symptoms associated with various psychiatric conditions. Clinically, it is favored for its favorable side effect profile compared to older antidepressants, though common adverse effects may include nausea, insomnia, dry mouth, and sexual dysfunction. It is typically administered orally once daily, with dosage titration based on individual patient response and tolerance.
Beyond human medicine, research continues to explore potential applications in pediatric populations and off-label uses for premenstrual dysphoric disorder. The drug is available under various brand names globally, most notably Zoloft, and is often included in essential medicines lists due to its efficacy and safety. While generally well-tolerated, abrupt discontinuation can lead to withdrawal symptoms, necessitating gradual dose reduction under medical supervision. With over two decades of clinical use, Sertraline remains a cornerstone pharmacotherapy in modern psychiatry, offering patients a reliable option for managing chronic mental health challenges and improving overall quality of life through balanced neurochemical regulation.
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