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Salcaprozate Sodium (SNAC);SODIUM 8-(2-HYDROXYBENZAMIDO)OCTANOATE (SNAC)

Category:

Other Excipients

CAS NO:

203787-91-1

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Guangzhou Congen Pharmatec Co.,Ltd.

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Basic Info

CAS Number

203787-91-1

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Packaging & Delivery

Packaging Specification

1kg/bag, 5kg/drum, 20kg/drum, 100kg/drum

Minimum Order Quantity

Delivery Cycle

2weeks

Product Description

Color: White to off-white

Solid form:powder

Purity：≥99%

SNAC is a bisphosphonate absorption enhancer used to treat gastrointestinal diseases, especially gastrointestinal diseases caused by bisphosphonate malabsorption.

AI Product Description

*The following content is generated by AI and is for reference only.

Salcaprozate Sodium, commonly abbreviated as SNAC, is a chemically synthesized absorption enhancer with the systematic name Sodium 8-(2-hydroxybenzamido)octanoate. Its molecular formula is C16H22NNaO4, and it carries the CAS Registry Number 207539-39-9. This compound functions primarily by transiently opening tight junctions between epithelial cells in the gastrointestinal tract, thereby facilitating the paracellular transport of macromolecules that are otherwise poorly absorbed. SNAC has gained significant attention in pharmaceutical research and development, particularly for oral delivery systems targeting peptides, proteins, and other biologics. Traditionally, such therapeutic agents require subcutaneous or intravenous injection due to their susceptibility to enzymatic degradation in the stomach and inability to cross intestinal membranes. SNAC overcomes these barriers by acting as a reversible permeation enhancer. It interacts with the lipid bilayer of cell membranes, inducing a temporary structural rearrangement that allows large molecules like insulin, calcitonin, and vaccines to pass through the gut lining into systemic circulation without causing permanent tissue damage. The mechanism involves the formation of micelles and interaction with tight junction proteins, specifically occludin and claudins, which loosens the barrier function momentarily. Once the drug passes through, the tight junctions rapidly reseal, minimizing local irritation. This unique property makes SNAC a versatile excipient suitable for various formulations, including tablets, capsules, and powders. It is widely recognized for its safety profile, exhibiting low toxicity and high biocompatibility when used within approved dosage ranges. Consequently, SNAC plays a pivotal role in advancing non-invasive drug delivery technologies, offering patients improved compliance and quality of life by replacing painful injections with convenient oral medications. Ongoing clinical studies continue to validate its efficacy across diverse therapeutic areas, solidifying its status as a cornerstone in modern oral biologic formulation strategies.