Sacubitril Valsartan Sodium
*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Sacubitril Valsartan Sodium is a <strong>fixed-dose combination</strong> of an angiotensin receptor-neprilysin inhibitor. It features the CAS number <strong>1420968-74-4</strong> with molecular formula C<sub>45</sub>H<sub>51</sub>N<sub>6</sub>O<sub>10</sub>. Core synthesis involves coupling sacubitril sodium with valsartan.</p>
<h3>Application</h3>
<ul>
<li><strong>Cardiovascular Therapy:</strong> Treatment of chronic heart failure to reduce cardiovascular mortality and hospitalization.</li>
<li><strong>Pharmaceutical Manufacturing:</strong> Bulk API production for tablet formulations in global markets.</li>
</ul>
<h3>Precautions</h3>
<p>Contraindicated in patients with history of angioedema or severe renal impairment. Store API in controlled humidity below 25°C to prevent hydrolysis. Strict adherence to GMP standards required during handling.</p>