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<h3>Overview</h3>
<p><strong>Rupatadine fumarate</strong> (CAS 182349-12-8) is a non-sedating antihistamine with dual H1 receptor antagonism and platelet-activating factor (PAF) inhibition. Synthesized via condensation of rupatadine base with fumaric acid, its molecular formula is C<sub>26</sub>H<sub>27</sub>N<sub>3</sub>O<sub>5</sub>.</p>
<h3>Application</h3>
<ul>
<li>Treatment of chronic idiopathic urticaria in adults.</li>
<li>Management of seasonal allergic rhinitis symptoms.</li>
<li>Pharmaceutical formulation as API for tablet manufacturing.</li>
</ul>
<h3>Precautions</h3>
<p>Contraindicated in patients with severe hepatic impairment or concomitant use of strong CYP3A4 inhibitors. Store in cool, dry conditions below 25°C away from light. Avoid inhalation of dust; wear appropriate PPE during handling.</p>