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CAS NO:
1260811-22-0
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Basic Info
CAS Number
1260811-22-0
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Roxatidine acetate, commonly referred to as Roxatidine, is a potent histamine H2-receptor antagonist widely utilized in the management of acid-related gastrointestinal disorders. Its primary molecular formula is C18H27NO4, and it carries the unique CAS Registry Number 60955-62-4 for its active free base form or 63597-23-9 for the acetate salt. This pharmaceutical agent functions by selectively blocking histamine at the H2 receptors located on the parietal cells within the gastric mucosa. By inhibiting this specific receptor pathway, Roxatidine effectively suppresses both basal and stimulated gastric acid secretion, including acid production triggered by food intake or pentagastrin stimulation.
Clinically, Roxatidine is primarily indicated for the treatment of peptic ulcers, encompassing both duodenal and gastric varieties. It promotes ulcer healing and provides significant relief from associated symptoms such as epigastric pain, heartburn, and indigestion. Furthermore, it is frequently employed in the prevention of stress ulcers in critically ill patients and serves as an adjunct therapy for gastroesophageal reflux disease (GERD). The drug demonstrates a favorable safety profile with minimal anticholinergic side effects compared to earlier generation H2 blockers. Its onset of action is relatively rapid, offering sustained acid suppression that allows for convenient dosing regimens, often involving once-daily administration for maintenance therapy.
Beyond its therapeutic applications, Roxatidine plays a crucial role in reducing the risk of aspiration pneumonia in surgical patients by maintaining higher gastric pH levels. Extensive pharmacological studies have confirmed its efficacy in accelerating mucosal repair and preventing recurrence of ulcers when used according to prescribed guidelines. While generally well-tolerated, minor adverse events may include headache, dizziness, or transient gastrointestinal disturbances. As a key component in modern gastroenterology, Roxatidine remains a valuable tool for clinicians managing chronic acid hypersecretion and facilitating the recovery of patients suffering from upper gastrointestinal tract pathologies.
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