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CAS NO:
119302-91-9
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Basic Info
CAS Number
119302-91-9
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Rocuronium Bromide is a widely utilized aminosteroid neuromuscular blocking agent, primarily employed in clinical anesthesia to facilitate endotracheal intubation and provide skeletal muscle relaxation during surgical procedures. Chemically, its molecular formula is C31H40BrN2O4, and it carries the CAS registry number 119302-91-9. As a non-depolarizing competitive antagonist at nicotinic acetylcholine receptors located at the neuromuscular junction, Rocuronium effectively prevents acetylcholine from binding to these receptors, thereby inhibiting nerve impulse transmission to muscles and inducing temporary paralysis. This mechanism allows surgeons to perform operations requiring absolute immobility without the need for deep general anesthesia levels that might compromise hemodynamic stability.
The drug is characterized by its rapid onset of action, which distinguishes it from many other agents in its class. Depending on the dosage administered, intubation conditions can often be achieved within sixty seconds, making it an ideal choice for rapid sequence induction in emergency settings or routine surgeries where quick airway management is critical. Its duration of action is intermediate, typically lasting between thirty to forty minutes, though this can vary based on patient-specific factors such as age, weight, and renal or hepatic function. Unlike succinylcholine, Rocuronium does not cause hyperkalemia or malignant hyperthermia, offering a safer profile for patients with specific contraindications to depolarizing agents. However, its effects are reversible; the administration of sugammadex, a selective relaxant-binding agent, can rapidly reverse the blockade even after profound neuromuscular block has occurred, enhancing patient safety and recovery speed.
Manufactured as a sterile powder for injection, Rocuronium Bromide must be stored under controlled conditions to maintain stability. It is supplied in various strengths to accommodate different patient populations and procedural requirements. While generally well-tolerated, potential side effects may include transient hypotension or tachycardia, particularly when administered rapidly in high doses. Overall, Rocuronium Bromide remains a cornerstone in modern anesthesiology, providing reliable muscle relaxation with a favorable safety profile and versatile reversibility options.
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