Category:
Preclinical Research Services
CAS NO:
625115-52-8
Standard:
ChP,
Products
Products
Suppliers
News
Search
All Categories
Products or Suppliers
Content Hub
Product Zone
Sponsorship & Membership
CPHI & PMEC China
Active Pharmaceutical Ingredients
Intermediates&Fine Chemicals
Bio Products
Natural Extracts
Finished Dosage
Pharmaceutical Excipients
Pharmaceutical Outsourcing, Customised Services, and Consulting
Medical Aesthetic Skincare
Food Ingredients
API Equipment
Preparation Equipment
Pharmaceutical Packaging Machinery
TCM Machinery
Pharmaceutical water equipment
Clean Technology
Refrigeration Equipment
Parts and Components
Informatization Products
Laboratory
Packaging Materials
Measuring Instrument
Environmental Protection Equipment
Logistics
Other Consumables
Dietary Supplements
Correctives
Colorant
Filtration separation
Intelligent Logistics
Cold chain Technical &Materials
Logistics Equipment &Materials
Storage Equipment &Materials
Logistic Services
Third-party logistics
Dangerous Goods Logistics
Level instrument
Pressure gauge
Thermometers
Flow meter
Gas analysis instrument
Liquid analysis instrument
Fermenter Equipment
Other Measuring Instrument
Other Logistics
Medical Aesthetic Consumables
Sera and Vaccines
Soft tube/Hard tube
Pharmaceutical Intermediates
Anti-tumor Preparations
Pharmaceutical Manufacturing Outsourcing
Chemical and Biochemical Reactors
Mixing Equipment
CIP System(Clean in place)
Herbal medicine Concentration Equipment
Purification Equipment
Low Temperature Refrigeration
Seals
Laboratory General Equipment
Functional Food Raw Materials
Inner packaging equipment
Polluted Water / Wastewater Treatment Equipment
Injection Raw Materials and Ingredients
IVD (In Vitro Diagnostics) Consumables
Suspending Agents / Thickening Agents
Concentrator Equipment
MES System
APIs for Anti-Infective Drugs
Biochemical APIs
Botanical products
Pharma Packaging Materials
Diluents (Fillers)
Intermediates for Agrochemicals
Reagent
Cardiovascular, Cerebrovascular, and Circulatory System Formulations
Pharmaceutical R&D Outsourcing
Drying Equipment
TCM Pulverizer
Water Purification Equipment
Purification Test Instrument
Air Conditioner
Sanitary Fittings
Analytical Instrument
Other Dipstick Consumables
Nutraceutical Ingredients
Granules Machinery
Outer packaging
Waste Gas Treatment Equipment
Active Ingredients
Binders
Solubilizers
Drug delivery systems
Sensors
APIs for Nervous System Drugs
Animal-derived products
Endocrine and Metabolic Preparations
Disintegrants
service
Crystalling Equipment
Pill Making Equipment
Other Water Treatment Equipment
Clean Clothes/Clean Cap/Clean Shoes
Cold Storage
Pumps
Food & Beverage Raw Materials
Life Science Instrument
Tablet equipment
Other pharmaceutical packaging equipment
Solid and Hazardous Waste Treatment Equipment
Innovative Materials
Controllers & Drivers
Speciality Intermediates
Microbial products
Humectants
APIs for Digestive System Drugs
APIs for Cardiovascular System Drugs
Antibacterial and Antiviral Formulations
Lubricants
Extraction Plant
Slice Machine
Clean Bench
Refrigeration Auxiliaries
Valves
Biologics
TCM Raw Materials
Food Additive
Reagents and Consumables
Capsule equipment
Pharmaceutical water equipment
Testing & Monitoring Instruments and Equipment
Other Medical Aesthetics & Skincare
Veterinary Pharmaceutical Intermediates
Automation Software
APIs for Respiratory System Drugs
Bio Technology Service
Antipyretic and Analgesic Preparations
Glidants / Anti-caking Agents
Heat Exchanger
Herbal medicine Drying Equipment
Air Shower Room
Compressor
Cylinders
Fine Chemicals
Crushing equipment
Ultrapure Water System
Other Automation & Informatization Products
OEM/ODM
Measuring Instruments
Energy-saving and Low-carbon Equipment
Other Intermediates
Antiparasitic Preparations
Coating Agents
Storage Tanks, Containers
Herbal medicine Extraction Equipment
Air Purification
Other Refrigeration Equipment
Drive Equipment
Liquid preparation equipment
Solution Preparation System
Other Environmental Protection Equipment
APIs for Hormones and Regulatory Drugs
Other Natural Products
Physical Testing
APIs for Antiparasitic Drugs
Anti-Allergic Formulations
Plasticizer
Evaporating Equipment
TCM Cooking Equipments
Cleanroom
Reducers
Laboratory Engineering
Biopharmaceutical Equipment
Membrane Module
APIs for Antipyretic and Analgesic Drugs
Anti-Tuberculosis and Anti-Leprosy Formulations
Surfactant
Distillation Equipment
Drop Pill Equipment
Purifying Engineering
VFD (Variable Frequency Drive)
Other preparation equipment
Distilled water machine
Laboratory Solutions
Vitamin
Digestive System Preparations
Centrifuge
Screening Machine
Honey Pill Machine
Flooring Materials
Bearing
Emulsifiers
Ion-exchange equipment
Online Process Control
Respiratory System Preparations
Sterilizing Equipment
TCM Deposition Equipment
Spare Part
Other Cleaning System
Stainless Steel
Nervous System Preparations
Filter press equipment
Herbal medicine Fermentation Equipment
Plastic
Containment System
Special Active Ingredients
Ointment Bases
Homogenizer Equipment
Other TCM Machinery
Others Parts and Components
APIs for Veterinary Drugs and Feed Additives
Anaesthetic and Adjuvant Formulations
Air Filter
Suppository Bases
Other Active Pharmaceutical Ingredients
Blood System Formulations
Cleanroom Consumables
Glass lining equipment
Film-forming Agents
Urinary and Reproductive System Formulations
Other API Machinery and Equipment
Filter Paper
Release Modifiers
Immunomodulatory Formulations
Filter Paper Board
smotic Pressure Regulators / Tonicity Adjusting Agents
Water, Electrolyte, and Acid-Base Balance Regulating Formulations
Ph Control Agents
Nozzle, Tank Cleaning Machine
Vitamin, Mineral, and Amino Acid Formulations
Antioxidants / Antioxidant Synergists
Fluid Equipment
Enzyme and Other Biochemical Formulations
Antimicrobial Preservatives (Preservatives)
Tonic and Nutritional Formulations
Complexing Agents (Chelating Agents / Inclusion Compounds)
Hormonal Formulations
Dermatological Preparations
Other Preparations
Co-solvents
ENT Preparations
Penetration Enhancers (Transdermal)
Freeze-drying Protective Agents
Refrigerants / Cryogens
Capsule
Fragrances
Adsorbents
Pressure-sensitive Adhesives (PSA)
Stiffening Agents
Carriers for Dry Powder Inhalers (DPI Carriers)
Other Excipients
Pipes and Pipe Fittings
Vacuum Equipment
Air Compressor
Compressor
Other Fluid Equipment
Prefillable Syringes
Filters
Filter Presstem
Filtration System
Filter Bag
Filter Mesh
Filter Cloth
Filter Membrane
Other Filtration Equipment
Sanitary Pressure Vessel
Hyaluronic Acid
Collagen
Botulinum Toxin
Peptide
Other Injection Raw Materials and Ingredients
Ceramide
Ectoin
Niacinamide
Asiaticoside
Ergothioneine
Chitosan
Other Active Ingredients
Chiral Intermediates
Advanced Intermediates
Microfiltration
Ultrafiltration
Auxiliary Equipment
Separation equipment
Metered Dose Inhalers
Dry Powder Inhalers
Penicillin
Hormones
Central Nervous System Drugs
Reagents for Biopharmaceuticals
Drug Target Discovery and Validation
Plant Extracts
Animal Extracts
Synthesis/Screening
Process Development/Optimisation/Scale-Up Production
Drug Registration and Submission Services
Ointment Filling-sealing Machine、Vacuum Mixer
Eye Drug Machinery
Soft Gelatin Capsule Machinery
Tablet Press
Pneumatic Cracker
Granulator
Labelers, Label Printers
Bag Packaging Machine
Thermostatic / Heating / Drying Equipment
Chromatography
Particle Size / Particle / Powder Analysis Instruments
Tabletop
Glass bottles & Vials
Fermentation Products
Prophylactic Biological Products
Mixing Tank/Blender
Bioreactor
Intravenous Infusion Set Assembly Equipment(Pen Assembly Equipment)
PCR
Recombinant Collagen
Alkaloids
Veterinary API
Regulated Fine Chemicals
Peptides
Balances / Weighing Scales
Online Gas Chromatography
Cephalosporins
Anesthetics
Immunology Reagents
Drug Development Technologies
Pharmaceutical Chemistry
Formulation Design
Regulatory and Compliance Consulting
Syrup Machinery
Injection Medicine Machinery
Hard Capsule Filling Machine
Coating Machine
Medicine Material Grinding Machine
Lettering machine
Box Packaging Machine
Mass Spectrometry
Laboratory Bench
Aluminum Foil
Rheometers / Viscometers
Chemical Reagents
Cleaning & Disinfection Equipment
Granulator
Emulsifier
Biological Fermentation System
Injection Molding Equipment
Exosome
Phospholipids
Prostaglandins
Veterinary Biologics
Chemical Reagents
Therapeutic Biological Products
Biochemical Reagents
Antibodies
Natural Pigments
Animal Lipids
Enzyme Preparations
Flowmeters
Online Particle Size Analyzer
Tetracycline
Amino Acids and Derivatives
Process Optimization and Testing
Nucleic Acids and Derivatives
Pre-Clinical Research
Chemical/Biological API Manufacturing
Powder Filling Machine
Oral Liquid Machinery
Low Temperature Pulverizer
Strapping machine
Paper Film Packaging Machine
Thermal Analyzers
Spectrometers
Other Measurement and Metrology Instruments
Storage Cabinets
Plastic Bottles
Other Industrial Process Control and Online Analytical Instruments
Certification
Feed Additives
Diagnostic Biological Products
Pulverizer
Coating Machine
Capsule Filling Machine
Other Mixing Equipment
Cell Engineering Equipment
Pre-filled Syringe Production Equipment
Purification Equipment
Electrophoresis/Gel Imaging/UV Detection
Regenerative Materials
Other Fine Chemicals
Cell Biology Reagents
Biological Consumables
Feed Additives
Soft Mist Inhaler
Plant Polysaccharides
Animal Proteins
Microbial Polysaccharides
Aminoglycoside
Enzymes
Molecular Biology Reagents
Clinical Trials
Intermediate Synthesis and Production
Market and Business Strategy Consulting
Suppository Drug Machinery
Powder Injection Machinery
Pharmaceutical Milling Machinery
Printing Device
Blister Packaging Machine
Environmental Test Chambers
Moisture Analyzer
Air Discharge Equipment
Rubber Stopper
Tablet Press
Other Tablet Equipment
Capsule Production Line
Isolator
Synthesis/Reaction Equipment
Microbial Detection Instrument
Composite Biomaterials
Animal Breeding Auxiliary Products
Packaging Testing Equipment
Laboratory Glassware and General Consumables
Preclinical Research Services
Nebulizer
Essential Oils
Animal Polysaccharides
Bioactive Functional Ingredients
Macrolides
Microbial / Fermentation Reagents
Proteins
Other Technology Services
Biotechnology Services
Formulation Development and Manufacturing
Other Services
Medicine Film Drug Machinery
Infusion Medicine Machinery（中文站有输液剂机械的三级分类）
Pharmaceutical Machine Milling
Instruction Booklet Folding Machine
Fan
Chromatography Consumables and Accessories
Other Physical Properties Testing Instruments
Gasket
Sample Preparation / Digestion Equipment
X-ray Structure Analysis
Safety Cabinet
Counting Machine (Tablet)
Other Capsule Filling Equipment
Disposable Biotechnology Equipment
Vacuum Packaging Machine
Laboratory Low-temperature Storage
Other Innovative Materials
Other Veterinary
Conveying equipment
Natural Spices
Bile Acids and Active Ingredients
Sulfonamides
Other Specialized Reagents
Computational Chemistry and AI-Assisted Drug Design
Clinical Trial Drug Manufacturing
Aerosol Drug Machinery
Super Micro Mill
Bottle Conveyer
Bundling Packaging Machine
Mixing/Dispersion Equipment
Other Laboratory Complete & Ancillary Equipment
Trays
Other Laboratory Consumable
Other Preparation Machinery for Solid Medcine
Centrifugal Separation System
Automatic Packaging Machine
Other Analytical Instrument
Chip System/Accessories
Cytokines
Counting Machine
Cartridge Vial
Medicinal Herbs
Bee Products
Chloramphenicols
Testing
Other Pharmaceutical Manufacturing Outsourcing
Medicine Filling Machine
Disk Type Bottle Straightening Machine
Lidding Materials
Other Crushing Equipment
Ultrafiltration/Microfiltration System
Horizontal Pillow Packaging Machine
Cartoning Machine
Auto-injector
Transfection/Cell Fusion
Track & Trace
Gas Generators / Gas Handling Equipment
Blood Products
TCM Ingredients & Slices
Animal Medicinal Materials
Lincomycin
Microbial Products
Bottle Washer
Vial Sealing Machine
Liquid Handling Equipment
Hoses and Fittings
Other Biopharmaceutical Equipment
Vertical Packaging Machine
Casing Machine
Microplate Reader/Enzyme Labeling Instrument
Analysis and Validation
Serialization System
Pen Injector
Other Anti-Infective Drug
Other Pharmaceutical R&D Outsourcing
Conveyer For Medicine Material
Spray Pump
Other Injectable Equipment
Aluminum Foil Packaging Machine
Coding Machine
Cell Analysis
Automated Assembly
Other Laboratory General Equipment
Packaging Bag Valve
Freeze Dryer
Granule packaging machine
Other Drug Delivery Device Accessories
Biological Microscope/In Vivo Imaging
Other Antibiotics
Cap Screwing Machine
Nasal Drug Delivery Devices / Nasal Spray Pumps
Printing Services
Liquid Packaging Machine
Laboratory Automation
Screw Capping Machine
Lamp Inspection Machine
Ophthalmic Drug Delivery Devices / Eye Drop Delivery Systems
Labelling
Powder Packaging Machine
Synthesizer
Heat Shrink Packaging Machine
Metal Detector
Insulin Pens / Blood Glucose Management Devices
Security Taggants & Markings
Filter Cartridge
Tablet Packaging Machine
Animal Experiment Instrument
Injection & blow molding machines
Batching system
Self-Injection Systems / Safety Protection Devices
Incubator Equipment
Printed Drugs Packaging
Box filling & sealing machine
Palletizing equipment
CIP cleaning system
Topical / Gynecological / Intimate Drug Delivery Devices
Desiccants
Other Life Science Instrument
Bottle Filling Line
Contaners
Lifting Charging Machine
Others
Inhalant Packaging
BFS Bottlepack Machine
Weighting Equipment
Blister Packaging Machine
Pharmaceutical Paper
Other Pharmaceutical Outer Packaging Equipment
Packaging bag valve
Container Sealing Machine
Glass Tube
Multi-functional Bottle Packaging Machine
Medical Aesthetic Freeze-Dried Powder Vials
Sachets Cartoner Packing line
Primary Packaging
Other Pharmaceutical Inner Packaging Equipment
Aluminum Caps & Aluminum-Plastic Combination Caps
Sterile Bags / Breathing Bags / Sterilization Bags
Medical Device Packaging / Bioconsumables Packaging
Dispensing Bottles
Blister Packaging
Pharmaceutical Plastic Films / Composite Film Bags
Accessories
Ampuls
Other Packaging Materials
Basic Info
CAS Number
625115-52-8
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Riociguat is a novel oral medication classified as a soluble guanylate cyclase (sGC) stimulator, designed to treat specific cardiovascular conditions. Its molecular formula is C23H24N6O2S, and it carries the CAS registry number 157902-78-0. This compound functions by directly activating sGC in vascular smooth muscle cells, independent of nitric oxide presence. Upon activation, sGC catalyzes the conversion of guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP). Elevated cGMP levels trigger a cascade of intracellular events leading to vasodilation, which reduces pulmonary vascular resistance and improves blood flow through the lungs.
The primary clinical indication for Riociguat is chronic thromboembolic pulmonary hypertension (CTEPH) in patients who are not candidates for curative pulmonary endarterectomy surgery or have persistent or recurrent disease after such procedures. Additionally, it is approved for the treatment of pulmonary arterial hypertension (PAH), specifically World Health Organization Group 1 PAH, to improve exercise capacity and delay clinical worsening. By enhancing the nitric oxide-cGMP pathway, Riociguat addresses the underlying pathophysiology of these diseases, where endothelial dysfunction leads to vasoconstriction and vascular remodeling.
Unlike phosphodiesterase-5 inhibitors, which prevent the breakdown of cGMP, Riociguat stimulates its production directly, offering a distinct mechanism of action that can be effective even when nitric oxide signaling is impaired. The drug is administered orally, typically starting at a low dose and titrated up based on patient tolerance and hemodynamic response. Common side effects include headache, hypotension, dizziness, nausea, and dyspepsia. Clinicians must carefully monitor blood pressure and avoid concurrent use with nitrates or other potent vasodilators due to the risk of severe hypotension. Furthermore, Riociguat is contraindicated during pregnancy because animal studies have shown teratogenic effects. As a targeted therapy, Riociguat represents a significant advancement in managing complex pulmonary hypertension disorders, providing improved quality of life and survival outcomes for patients with limited therapeutic options. Its unique pharmacological profile continues to make it a cornerstone in modern cardiopulmonary medicine.
Other Products From This Supplier
More
Follow Us
Contact Us
About Us
Buy Service
Sell Service
Follow Us
Copyright 2006-2025 
(All Rights Reserved)
(All Rights Reserved)
Copyright 2006-2025 (All Rights Reserved)
(All Rights Reserved)