Rink Amide MBHA 1.0% 0.3mmol/g~0.6mmol/g 100~200mesh ; 200~400mesh
Rink Amide MBHA 1.0% 0.6mmol/g~0.8mmol/g 100~200mesh200~400mesh
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*The following content is generated by AI and is for reference only.
Rink Amide MBHA (4-[(4,4-Dimethyl-2,6-dioxocyclohexylidene)methyl]benzylamine) with a loading capacity of 1.0% (0.5 mmol/g) is a critical solid support reagent widely utilized in automated and manual peptide synthesis. Chemically, it serves as the linker connecting the growing peptide chain to the polystyrene resin matrix while simultaneously providing an amide functionality at the C-terminus upon cleavage. The "MBHA" designation refers to the 4-methylbenzhydrylamine moiety, which is standard for generating C-terminal amides rather than free carboxylic acids. This specific product features a loading density of 0.5 mmol per gram of resin, indicating that each gram contains approximately 0.5 millimoles of reactive Rink amide groups available for coupling reactions.
The primary application of this reagent is the synthesis of peptides ending in an amide group, a structural motif essential for mimicking natural biological peptides found in proteins and hormones. Many bioactive peptides require a C-terminal amide for optimal stability, receptor binding affinity, and resistance to enzymatic degradation by carboxypeptidases. By utilizing Rink Amide MBHA resins, chemists can efficiently produce these therapeutically relevant sequences using standard Fmoc (9-fluorenylmethoxycarbonyl) or Boc (tert-butyloxycarbon yl) protection strategies. The cleavage process typically employs strong acidic conditions, such as trifluoroacetic acid (TFA) mixtures containing scavengers, which liberate the peptide from the resin without compromising side-chain protecting groups when appropriate.
This high-loading resin ensures efficient utilization of raw materials and simplifies purification processes due to its robust mechanical properties and consistent bead morphology. It is compatible with various automated synthesizers, making it a staple in pharmaceutical research, drug discovery pipelines, and academic laboratories focused on peptidomimetics. Researchers rely on this material to accelerate the development of novel peptide-based drugs, including those targeting oncology, infectious diseases, and metabolic disorders. Its reliability in producing homogeneous products with defined C-terminal structures makes it indispensable for modern medicinal chemistry.