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CAS NO:
968-86-5
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ChP,
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Basic Info
CAS Number
968-86-5
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Remifentanil is a potent, short-acting synthetic opioid analgesic belonging to the phenylpiperidine class. Its chemical structure is defined by the molecular formula C19H28N2O5S and it is identified by the CAS Registry Number 132804-97-2. Unlike other opioids in its class, Remifentanil possesses a unique ester linkage that renders it susceptible to rapid hydrolysis by non-specific plasma and tissue esterases. This distinctive metabolic pathway allows for an extremely rapid onset of action and a context-sensitive half-life of merely three to four minutes, regardless of the duration of infusion. Consequently, it offers unparalleled control over the depth of anesthesia and analgesia during surgical procedures.
Clinically, Remifentanil is primarily utilized as an adjunct in general anesthesia for induction and maintenance. It is particularly valuable in outpatient surgeries, cardiac procedures, and neurosurgery where rapid emergence from anesthesia is critical for patient safety and quick recovery. The drug provides profound analgesia without significant respiratory depression accumulation, although transient apnea may occur immediately after administration or dose escalation. Due to its ultra-short duration, it is often combined with other sedatives like propofol to maintain hemodynamic stability while minimizing postoperative residual effects.
The product is supplied as a lyophilized powder containing remifentanil hydrochloride, which must be reconstituted with sterile water before intravenous administration. While highly effective, its use requires precise titration and continuous monitoring by trained anesthesiologists due to the risk of chest wall rigidity, bradycardia, and hypotension. Furthermore, abrupt discontinuation can lead to acute opioid withdrawal symptoms if not managed carefully. Despite these challenges, Remifentanil remains a cornerstone in modern anesthetic practice, offering unmatched pharmacokinetic predictability and facilitating efficient operating room turnover. Its development marked a significant advancement in perioperative care, enabling surgeons and anesthesiologists to tailor pain management strategies with exceptional precision for complex and time-sensitive medical interventions.
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