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Products

Preclinical Research Services

Relebactam

Category:

Preclinical Research Services

CAS NO:

N/A

Standard:

ChP,

Price Range:

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Main Sales Markets:

Europe,Asia,South America,Africa,Middle East

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China National Standard Pharmaceutical Co., Ltd.

Years

Show Room

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Basic Info

CAS Number

N/A

Pharmacopoeia

ChP

Grade

In-house Standards

Is Manufacturer

YES

Packaging & Delivery

Minimum Order Quantity

Any

Delivery Cycle

Negotiable

Product Description

Reference Standards &Impurity

AI Product Description

*The following content is generated by AI and is for reference only.

Relebactam is a novel beta-lactamase inhibitor belonging to the diazabicyclooctane (DBO) class, developed specifically to combat multidrug-resistant Gram-negative bacteria. Its primary molecular formula is C12H16N4O3S, with a corresponding CAS number of 1579088-93-3. This compound functions by irreversibly binding to and inhibiting Class A and Class C beta-lactamases, enzymes produced by resistant pathogens that typically degrade and neutralize beta-lactam antibiotics like carbapenems. By blocking these enzymatic mechanisms, Relebactam restores the efficacy of co-administered beta-lactams against difficult-to-treat organisms such as Klebsiella pneumoniae and Escherichia coli. Clinically, Relebactam is most notably utilized in combination with imipenem and cilastatin under the brand name Recarbrio. This fixed-dose combination is approved for the treatment of complicated intra-abdominal infections and complicated urinary tract infections, including acute pyelonephritis, caused by susceptible Enterobacteriaceae. The synergistic interaction between Relebactam and imipenem allows for effective bacterial eradication even when the pathogen produces metallo-beta-lactamases or other resistance mechanisms that would otherwise render standard therapies ineffective. Unlike traditional inhibitors such as clavulanic acid, Relebactam exhibits superior stability and potency against a broader spectrum of beta-lactamases without significant intrinsic antibacterial activity of its own. The development of Relebactam represents a critical advancement in the fight against antimicrobial resistance, addressing a growing global health crisis where conventional antibiotics are losing their therapeutic value. Its unique chemical structure enables it to penetrate the periplasmic space of Gram-negative bacteria efficiently, ensuring high local concentrations at the site of action. Extensive clinical trials have demonstrated its safety profile and efficacy, making it a vital tool for healthcare providers managing severe infections in hospital settings. As antibiotic stewardship becomes increasingly important, agents like Relebactam offer a promising strategy to extend the lifespan of existing beta-lactam classes and improve patient outcomes in cases involving resistant strains. Ongoing research continues to explore its potential applications in treating other infectious diseases, further solidifying its role in modern pharmacotherapy.